Evidence map›Paper›PMID 28916181›Full record

ArticleNeuroImage2017

Replicability of time-varying connectivity patterns in large resting state fMRI samples.

Anees Abrol, Eswar Damaraju, Robyn L Miller, Julia M Stephen, Eric D Claus, Andrew R Mayer, Vince D Calhoun

Abstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Switching Patterns of Cortical-Subcortical Interaction in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Aberrant brain dynamics in major depressive disorder during working memory task.European archives of psychiatry and clinical neuroscience · 2025
    Article
  14. Article
  15. Time Persistence of the FMRI Resting-State Functional Brain Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  16. Article
  17. Altered brain state dynamics between preterm and term-born infants.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  18. Article
  19. Article
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anees AbrolThe Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA. Electronic address: aabrol@unm.edu.
Eswar DamarajuThe Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.
Robyn L MillerThe Mind Research Network, Albuquerque, NM, USA.
Julia M StephenThe Mind Research Network, Albuquerque, NM, USA.
Eric D ClausThe Mind Research Network, Albuquerque, NM, USA.
Andrew R MayerThe Mind Research Network, Albuquerque, NM, USA.
Vince D CalhounThe Mind Research Network, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA.

Funding

Transcranial Direct Current Stimulation for Treatment of Auditory Verbal HalluciP20GM103472 · NIGMS · THE MIND RESEARCH NETWORK · PI ABBOTT, CHRISTOPHER C · 2012 to 2017
$14.3M
Multivariate methods for identifying multitask/multimodal brain imaging biomarkersR01EB006841 · NIBIB · THE MIND RESEARCH NETWORK · PI VINCE D CALHOUN, Sergey Plis · 2007 to 2026
$9.8M
COINSTAC: Decentralized, Scalable Analysis of Loosely Coupled DataR01DA040487 · NIDA · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, PLIS, SERGEY · 2015 to 2024
$7.1M
Informed Data-Driven Fusion of Behavior, Brain Function, and GenesR01EB005846 · NIBIB · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D · 2005 to 2016
$5.5M
Unified multivariate data-driven solutions for static and dynamic brain connectivityR01EB020407 · NIBIB · THE MIND RESEARCH NETWORK · PI ADALI, TULAY, CALHOUN, VINCE D · 2015 to 2018
$2.7M
NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB020407NIDA NIH HHS R01 DA040487NIGMS NIH HHS P20 GM103472
6 · The paper itself

Abstract

The past few years have seen an emergence of approaches that leverage temporal changes in whole-brain patterns of functional connectivity (the chronnectome). In this chronnectome study, we investigate the replicability of the human brain's inter-regional coupling dynamics during rest by evaluating two different dynamic functional network connectivity (dFNC) analysis frameworks using 7 500 functional magnetic resonance imaging (fMRI) datasets. To quantify the extent to which the emergent functional connectivity (FC) patterns are reproducible, we characterize the temporal dynamics by deriving several summary measures across multiple large, independent age-matched samples. Reproducibility was demonstrated through the existence of basic connectivity patterns (FC states) amidst an ensemble of inter-regional connections. Furthermore, application of the methods to conservatively configured (statistically stationary, linear and Gaussian) surrogate datasets revealed that some of the studied state summary measures were indeed statistically significant and also suggested that this class of null model did not explain the fMRI data fully. This extensive testing of reproducibility of similarity statistics also suggests that the estimated FC states are robust against variation in data quality, analysis, grouping, and decomposition methods. We conclude that future investigations probing the functional and neurophysiological relevance of time-varying connectivity assume critical importance.

Indexed as

AdolescentAdultAgedBrainBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural PathwaysReproducibility of ResultsRestYoung AdultDynamic functional connectivityFuzzy meta-stateHard clusteringReplicabilitySliding window methodSurrogate testing

Identifiers

PMID28916181
PMCPMC5775892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.