Evidence map›Paper›PMID 28916168›Full record

ArticleDevelopmental biology2019

Scripting a place in time.

Thomas B Kornberg

Abstract read
In one paragraph

Article in Developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Geometry of gene regulatory dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Review
  4. A mammalianeLife · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Thomas B KornbergCardiovascular Research Institute, University of California, San Francisco, CA 94143, United States. Electronic address: tkornberg@ucsf.edu.
University of California, San Francisco · US

Funding

Molecular Mechanisms in DevelopmentR35GM122548 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS B. KORNBERG · 2017 to 2026
$8.8M
MOLECULAR MECHANISMS IN DEVELOPMENTR01GM030637 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORNBERG, THOMAS B. · 1985 to 2017
$6.8M
Gene regulation and function in early embryosR01GM109410 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORNBERG, THOMAS B. · 2014 to 2017
$1.2M
Hedgehog signaling and signal transductionR01GM105987 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORNBERG, THOMAS B. · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM030637NIGMS NIH HHS R01 GM105987NIGMS NIH HHS R01 GM109410NIGMS NIH HHS R35 GM122548
6 · The paper itself

Abstract

Evidence in many experimental systems supports the idea that non-uniform distributions of morphogen proteins encode positional information in developing tissues. There is also strong evidence that morphogen dispersal is mediated by cytonemes and that morphogen proteins transfer from producing to receiving cells at morphogenetic synapses that form at sites of cytoneme contacts. This essay considers some implications of this mechanism and its relevance to various contexts including large single cells such as the pre-cellular Drosophila embryo and the ciliate Stentor.

Indexed as

AnimalsCiliophoraDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianMorphogenesisProtozoan ProteinsSignal TransductionDrosophila ProteinsProtozoan ProteinsBicoidCytonemeGene expressionGradientMorphogen

Identifiers

PMID28916168
PMCPMC5849486
OpenAlexW2756008925

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.