Evidence map›Paper›PMID 28916130›Full record

ReviewTrends in neurosciences2017

Stress and Seizures: Space, Time and Hippocampal Circuits.

B G Gunn, T Z Baram

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Review
  3. Adrenal Crisis Induced-seizures: A Case Report and Literature Review.Journal of community hospital internal medicine perspectives · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Does Stress Trigger Seizures? Evidence from Experimental Models.Current topics in behavioral neurosciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

B G GunnDepartment of Pediatrics, University of California, Irvine, CA, USA.
T Z BaramDepartment of Pediatrics, University of California, Irvine, CA, USA; Department of Anatomy & Neurobiology, University of California, Irvine, CA, USA; Department of Neurology, University of California, Irvine, CA, USA. Electronic address: tallie@uci.edu.

Funding

Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Effects of Early-Life Experience: Role of CRHR01MH073136 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2005 to 2020
$4.6M
CRH-MRNA REGULATION--ROLE IN NEONATAL SEIZURE POTENTIALR01NS028912 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 1992 to 2014
$4.2M
FEBRILE SEIZURE MODEL--NEURONAL INJURY AND MECHANISMSR01NS035439 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 1997 to 2018
$3.2M
NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH073136NINDS NIH HHS R01 NS028912NINDS NIH HHS R01 NS035439
6 · The paper itself

Abstract

Stress is a major trigger of seizures in people with epilepsy. Exposure to stress results in the release of several stress mediators throughout the brain, including the hippocampus, a region sensitive to stress and prone to seizures. Stress mediators interact with their respective receptors to produce distinct effects on the excitability of hippocampal neurons and networks. Crucially, these stress mediators and their actions exhibit unique spatiotemporal profiles, generating a complex combinatorial output with time- and space-dependent effects on hippocampal network excitability and seizure generation.

Indexed as

AnimalsHippocampusHumansNeural PathwaysSeizuresStress, Psychologicalcorticosteronecorticotropin-releasing hormonecortisolepilepsyhippocampusnetworkneurosteroidseizurestress

Identifiers

PMID28916130
PMCPMC5660662

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.