ArticleBMC complementary and alternative medicine2017
Plectranthus amboinicus essential oil and carvacrol bioactive against planktonic and biofilm of oxacillin- and vancomycin-resistant Staphylococcus aureus.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current State of Knowledge Regarding WHO High Priority Pathogens-Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Antibacterial Activity of a Mouthwash Containing Plectranthus amboinicus (Lour.) Spreng Extract and Lippia sidoides Cham. Essential Oil.Chemistry & biodiversity · 2026Article
- Innovative essential oil formulations for in vitro inhibition of Biofilm-Forming Extended-Spectrum β-Lactamase-Producing Escherichia coli isolated from canine infectious diarrhea.Veterinary research communications · 2025Article
- Review
- Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review.Antibiotics (Basel, Switzerland) · 2025Review
- Anti-Antibiotics (Basel, Switzerland) · 2024Article
- Transcriptional Profiling of the Effect ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Evaluation of the Effect ofPathogens (Basel, Switzerland) · 2023Article
- Antifungal and Antibiofilm Activity of Colombian Essential Oils against DifferentAntibiotics (Basel, Switzerland) · 2023Article
- Microwave-Assisted Hydrodistillation of Essential Oil fromLife (Basel, Switzerland) · 2023Article
- Effects ofAntibiotics (Basel, Switzerland) · 2022Article
- Recent advances to combat ESKAPE pathogens with special reference to essential oils.Frontiers in microbiology · 2022Review
- Tackling Multiple-Drug-Resistant Bacteria With Conventional and Complex Phytochemicals.Frontiers in cellular and infection microbiology · 2022Review
- Sensitivity of Staphylococcal Biofilm to Selected Compounds of Plant Origin.Antibiotics (Basel, Switzerland) · 2021Review
- Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens.Frontiers in pharmacology · 2021Review
- Carvacrol Targets SarA and CrtM of Methicillin-ResistantACS omega · 2020Article
- Chemical Composition and Antimicrobial Effectiveness ofMolecules (Basel, Switzerland) · 2019Article
- Essential oils ofJournal of pharmaceutical analysis · 2019Article
- Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds.Future science OA · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe emergence of multidrug-resistant bacteria is a worldwide concern and in order to find an alternative to this problem, the occurrence of antimicrobial compounds in Plectranthus amboinicus essential oil was investigated. Thus, this study aims to determine susceptibility of Staphylococcus aureus isolated from food to antibiotics, P. amboinicus essential oil (PAEO) and carvacrol.
methodsLeaves and stem of P. amboinicus were used for extraction of essential oil (PAEO) by hydrodistillation technique and EO chemical analysis was performed by gas chromatography coupled to a mass spectrometer. S. aureus strains (n = 35) isolated from food and S. aureus ATCC 6538 were used to evaluate the antimicrobial and antibiofilm activity of PAEO and carvacrol. All strains (n = 35) were submitted to antimicrobial susceptibility profile by disk diffusion method. Determination of MIC and MBC was performed by microdilution technique and antibiofilm activity was determined by microtiter-plate technique with crystal violet assay and counting viable cells in Colony Forming Units (CFU).
resultsCarvacrol (88.17%) was the major component in the PAEO. Antibiotic resistance was detected in 28 S. aureus strains (80%) and 12 strains (34.3%) were oxacillin and vancomycin-resistant (OVRSA). From the 28 resistant strains, 7 (25%) showed resistance plasmid of 12,000 bp. All strains (n = 35) were sensitive to PAEO and carvacrol, with inhibition zones ranging from 16 to 38 mm and 23 to 42 mm, respectively. The lowest MIC (0.25 mg mL
conclusionThe antibacterial effect of carvacrol and PAEO proves to be a possible alternative against planktonic forms and staphylococcal biofilm.
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