Evidence map›Paper›PMID 28915663›Full record

ArticleOncotarget2017

MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma.

Alexandre Bozec, Joséphine Zangari, Mathilde Butori-Pepino, Marius Ilie, Salomé Lalvee, Thierry Juhel, Catherine Butori, Patrick Brest, Paul Hofman, Valérie Vouret-Craviari

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 38 citations in OpenAlex.

  1. [Research progress on the mechanisms of resistance to cetuximab targeted therapy in head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
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  19. miR-223-3p Inhibits Human Osteosarcoma Metastasis and Progression by Directly Targeting CDH6.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Alexandre BozecUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Joséphine ZangariUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Mathilde Butori-PepinoUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Marius IlieUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Salomé LalveeLaboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France.
Thierry JuhelUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Catherine ButoriLaboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France.
Patrick BrestUniversité Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Paul Hofman *Université Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Valérie Vouret-Craviari *Université Côte d'Azur, INSERM, CNRS, IRCAN, Nice, France.
Université Côte d'Azur · FRInstitut de Recherche sur le Cancer et le Vieillissement de Nice · FRBases, Corpus, Langage · FRCentre Antoine Lacassagne · FRCentre Hospitalier Universitaire de Nice · FRFondation ARC pour la Recherche sur le Cancer · FRHôpital Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRs) participate in tumor growth and dissemination by regulating expression of various target genes. MiR-223-3p is suspected of being involved in head and neck squamous cell carcinoma (HNSCC) growth although its precise role has not been elucidated. In this study, we showed that miR-223-3p is present in biopsies of HNSCC patients and that its presence is correlated with high neutrophil infiltrate. We found that overexpression of miR-223-3p slightly increased proliferation of the CAL27 squamous carcinoma cell line both

Indexed as

anticancer agentsinflammationMiRsneutrophilstumors

Identifiers

PMID28915663
PMCPMC5593634
OpenAlexW2734899337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.