Evidence map›Paper›PMID 28914813›Full record

ReviewInternational journal of molecular sciences2017

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis.

Luigi Rosa, Antimo Cutone, Maria Stefania Lepanto, Rosalba Paesano, Piera Valenti

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 2 pooled it
18.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 2 syntheses or guidelines pooled it, 353 citations in OpenAlex.

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122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luigi RosaDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. luigi.rosa@uniroma1.it.ORCID 0000-0002-1252-6080
Antimo CutoneDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. antimo.cutone@uniroma1.it.
Maria Stefania LepantoDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. mariastefania.lepanto@uniroma1.it.
Rosalba PaesanoDepartment of Gynecological-Obstetric and Urological Sciences, University of Rome La Sapienza, 00185 Rome, Italy. rosalba.paesano@uniroma1.it.
Piera ValentiDepartment of Public Health and Infectious Diseases, University of Rome La Sapienza, 00185 Rome, Italy. piera.valenti@uniroma1.it.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses. HLf and bovine Lf (bLf), possessing high sequence homology and identical functions, inhibit bacterial growth and biofilm dependently from iron binding ability while, independently, bacterial adhesion to and the entry into cells. In infected/inflamed host cells, bLf exerts an anti-inflammatory activity against interleukin-6 (IL-6), thus up-regulating ferroportin (Fpn) and transferrin receptor 1 (TfR1) and down-regulating ferritin (Ftn), pivotal actors of iron and inflammatory homeostasis (IIH). Consequently, bLf inhibits intracellular iron overload, an unsafe condition enhancing in vivo susceptibility to infections, as well as anemia of inflammation (AI), re-establishing IIH. In pregnant women, affected by AI, bLf oral administration decreases IL-6 and increases hematological parameters. This surprising effect is unrelated to iron supplementation by bLf (80 μg instead of 1-2 mg/day), but to its role on IIH. AI is unrelated to the lack of iron, but to iron delocalization: cellular/tissue overload and blood deficiency. BLf cures AI by restoring iron from cells to blood through Fpn up-expression. Indeed, anti-inflammatory activity of oral and intravaginal bLf prevents preterm delivery. Promising bLf treatments can prevent/cure transitory inflammation/anemia/oral pathologies in athletes.

Indexed as

HomeostasisAnemiaAnemia, Iron-DeficiencyAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsFemaleGlycoproteinsHumansInflammationIronLactoferrinOral HealthPregnancyPremature BirthProtein BindingAnti-Infective AgentsAnti-Inflammatory AgentsGlycoproteinsIronLactoferrinanemiaathletescytokineshomeostasisinflammationironlactoferrinoral care

Identifiers

PMID28914813
PMCPMC5618634
OpenAlexW2755877600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.