ArticleNeuroreport2017
Age-related resting-state functional connectivity in the olfactory and trigeminal networks.
Article in Neuroreport, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Dogs' olfactory resting-state functional connectivity is modulated by age and brain shape.Scientific reports · 2025Article
- Olfactory-trigeminal integration in the primary olfactory cortex.Human brain mapping · 2024Article
- Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum.Frontiers in neuroscience · 2024Review
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Human hippocampal connectivity is stronger in olfaction than other sensory systems.Progress in neurobiology · 2021Article
- Olfactory impairment in men and mice related to aging and amyloid-induced pathology.Pflugers Archiv : European journal of physiology · 2021Review
- Normal Olfactory Functional Connectivity Despite Lifelong Absence of Olfactory Experiences.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Brain networks for intranasal chemosensation have been shown to be intrinsically organized in humans . However, little is known about how changes in the intrinsic functional connectivity (FC) in chemosensory networks are related to aging. We, therefore, investigated the impact of age on resting-state FC in the olfactory and trigeminal networks (ON and TN) by combining two freely available resting-state fMRI data sets (obtained from the NITRC.org; Atlanta and New York) with data collected in our lab to generate a large sample size (N=103; 51 women) spanning the age range of 20-61 years. Seed regions were defined using Montreal Neurological Institute's coordinates that anchor ON and TN in activation studies and meta-analyses. The ON included the piriform cortex and the oribtofrontal cortex. The TN included the anterior insula and the cingulate cortex. Scanner site, sex, and age were used as covariates in group-level analyses. The FC between the ON and the parahippocampal gyrus was correlated negatively with age. The FC between the TN and the parahippocampal gyrus, however, was positively correlated. Similarly, age was correlated positively with the ON FC to the ventral striatum and the TN FC to the default mode network. These results reflect divergent age-related alterations in the intrinsic FC of the human chemosensory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.