ArticleeLife2017
Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review.Human brain mapping · 2020Pooled it
- Simultaneous single-cell calcium imaging of neuronal population activity and brain-wide BOLD fMRI.Nature methods · 2026Article
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- GCaMP fiber photometry reveals mechanistic insights into focused ultrasound neuromodulation in acute seizures.NPJ acoustics · 2026Article
- A brain-state-informed framework for simultaneous extinction of fear and functional magnetic resonance imaging acquisition in rodents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Systematic evaluation of adhesives for implant fixation in multimodal functional brain MRI.Magma (New York, N.Y.) · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Neurovascular coupling: a review of spontaneous neocortical dynamics linking neuronal activity to hemodynamics and what we have learned from the rodent brain.Journal of neurophysiology · 2025Review
- Temporal variability of brain-behavior relationships in fine-scale dynamics of edge time series.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Unresponsiveness induced by sevoflurane and propofol is associated with reduced basal forebrain cholinergic nuclei functional connectivity in humans,Neuroimage. Reports · 2024Article
- 4D dynamic spatial brain networks at rest linked to cognition show atypical variability and coupling in schizophrenia.Human brain mapping · 2024Article
- Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Group ICA of wide-field calcium imaging data reveals the retrosplenial cortex as a major contributor to cortical activity during anesthesia.Frontiers in cellular neuroscience · 2024Article
- From local properties to brain-wide organization: A review of intraregional temporal features in functional magnetic resonance imaging data.Human brain mapping · 2023Review
- Disentangling the impact of cerebrospinal fluid formation and neuronal activity on solute clearance from the brain.Fluids and barriers of the CNS · 2023Article
- Uncovering the organization of neural circuits with Generalized Phase Locking Analysis.PLoS computational biology · 2023Article
- Assessing brain state and anesthesia level with two-photon calcium signals.Scientific reports · 2023Article
- Intrinsic macroscale oscillatory modes driving long range functional connectivity in female rat brains detected by ultrafast fMRI.Nature communications · 2023Article
- Individual slow wave events give rise to macroscopic fMRI signatures and drive the strength of the BOLD signal in human resting-state EEG-fMRI recordings.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous slow oscillation-associated slow wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes of neuronal activity - slow wave events. However, it remains unclear which macroscopic signal is related to these active periods of the slow wave rhythm. We used optic fiber-based calcium recordings of local neural populations in cortex and thalamus to detect neurophysiologically defined slow calcium waves in isoflurane anesthetized rats. The individual slow wave events were used for an event-related analysis of simultaneously acquired whole-brain BOLD fMRI. We identified BOLD responses directly related to onsets of slow calcium waves, revealing a cortex-wide BOLD correlate: the entire cortex was engaged in this specific type of slow wave activity. These findings demonstrate a direct relation of defined neurophysiological events to a specific BOLD activity pattern and were confirmed for ongoing slow wave activity by independent component and seed-based analyses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.