Evidence map›Paper›PMID 28914373›Full record

SynthesisClinical rheumatology2017

The therapeutic effect of probiotics on rheumatoid arthritis: a systematic review and meta-analysis of randomized control trials.

Abdelrahman Tarek Mohammed, Mohammed Khattab, Ali Mahmoud Ahmed, Tarek Turk, Nora Sakr, Adham M Khalil, Mohamed Abdelhalim, Bisher Sawaf, Kenji Hirayama, Nguyen Tien Huy

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical rheumatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05790356 (Fecal Microbial Transplantation for Rheumatoid Arthritis Trial), which is not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 8 pooled it
12.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05790356 narecruitingnot on this mapstarted 2023, after this paper: background citation

Fecal Microbial Transplantation for Rheumatoid Arthritis Trial

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2023 to 2026Enrolled30ConditionsArthritis, Arthritis, Rheumatoid, Fecal Microbiota TransplantationArmsFecal Microbial transplant, Placebo capsules
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 8 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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  9. Effects ofNutrients · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Abdelrahman Tarek MohammedFaculty of Medicine, Al-Azhar University, Cairo, 11884, Egypt.
Mohammed KhattabFaculty of Medicine, Al-Azhar University, Cairo, 11884, Egypt.
Ali Mahmoud AhmedFaculty of Medicine, Al-Azhar University, Cairo, 11884, Egypt.
Tarek TurkFaculty of Medicine, Damascus University, Damascus, Syria.
Nora SakrFaculty of Medicine, Menoufia University, Menoufia, Egypt.
Adham M KhalilFaculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
Mohamed AbdelhalimFaculty of Medicine, Zagazig University, Zagazig, 44519, Egypt.
Bisher SawafFaculty of Medicine, Syrian Private University, Damascus, Syria.
Kenji HirayamaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Nguyen Tien HuyEvidence Based Medicine Research Group and Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam. nguyentienhuy@tdt.edu.vn.
Al-Azhar University · EGZagazig University · EGDamascus University · SYHo Chi Minh City Medicine and Pharmacy University · VNMenoufia University · EGNagasaki University · JPSyrian Private University · SY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis is an autoimmune disease in which probiotics appears to have an immune modulating action along with decreased inflammatory process. Therefore, we aim to investigate the efficacy of probiotics as an adjuvant therapy for rheumatoid arthritis. A comprehensive literature search was performed using nine databases including PubMed and Web of Science. Interesting data was extracted and meta-analyzed. We assessed the risk of bias using Cochrane Collaboration's tool. The protocol was registered in PROSPERO (CRD 42016036769). We found nine studies involving 361 patients who met our eligibility criteria. Our meta-analysis indicated that pro-inflammatory cytokine IL-6 was significantly lower in the probiotics compared with the placebo group (standardized mean difference = - 0.708; 95% confidence interval (CI) - 1.370 to 0.047, P = 0.036). However, there was no difference between probiotics and placebo in disease activity score (mean difference 0.023; 95% CI - 0.584 to 0.631, P = 0.940). Probiotics lowered pro-inflammatory cytokines IL-6 in RA; however, its clinical effect is still unclear. Hence, many high-quality randomized controlled trials (RCTs) are still needed to prove this effect.

Indexed as

Dietary SupplementsAntirheumatic AgentsArthritis, RheumatoidHumansProbioticsRandomized Controlled Trials as TopicTreatment OutcomeAntirheumatic AgentsCytokinesDisease activity scoreMeta-analysisProbioticsRheumatoid arthritisSystematic review

Identifiers

PMID28914373
OpenAlexW2755565506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.