Evidence map›Paper›PMID 28914356›Full record

ArticleParasitology research2017

In vivo treatment with nitazoxanide induces anaerobic metabolism in experimental intraperitoneal cysticercosis.

Joelma M Nasareth, Carolina M Fraga, Nayana F Lima, Guaraciara A Picanço, Tatiane L Costa, Ruy S Lino-Junior, Marina Clare Vinaud

Abstract read
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In one paragraph

Article in Parasitology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joelma M NasarethTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Carolina M FragaTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Nayana F LimaTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Guaraciara A PicançoTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Tatiane L CostaTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Ruy S Lino-JuniorTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil.
Marina Clare VinaudTropical Pathology and Public Health Institute, Federal University of Goias, Rua 235, s/n, Setor Leste Universitário, Goiânia, Goiás, 74605-050, Brazil. marinavinaud@gmail.com.
Universidade Federal de Goiás · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Taenia crassiceps cysticerci are used as experimental model to study the host-parasite relationship and treatment of cysticercosis. One of the described mode of actions of nitazoxanide (NTZ) is to block the pyruvate ferredoxine oxidoreductase (PFOR) enzyme which is an essential enzyme to the parasite metabolism. The aim of this study was to determine the in vivo influence of one dosage of NTZ on the energetic metabolism of T. crassiceps cysticerci. Thirty days after the intraperitoneal inoculation of T. crassiceps cysticerci, BALB/c mice were orally treated with 7.5 mg/kg of NTZ. The control group was treated with physiologic solution (NaCl 0.9%). After 24 h, the animals were euthanized and the cysticerci were removed, washed, and processed for biochemical analysis. The organic acids detection occurred through high-performance liquid chromatographic and spectrophotometric analysis. While there was no difference in the glucose dosages, it was possible to observe a significant increase in the lactate concentrations and a decrease in the pyruvate concentrations of the NTZ-treated groups when compared to the control group. Also, there was a decrease in the urea and alpha-ketoglutarate concentrations. This probably occurred due to the impairment of the parasite's PFOR and nitroreductases leading an impairment of the mitochondrial aerobic pathways. In conclusion, the in vivo NTZ treatment leads to an increase in the lactic fermentation and to a decrease in the protein catabolism in T. crassiceps cysticerci.

Indexed as

AnaerobiosisAnimalsAnticestodal AgentsChromatography, High Pressure LiquidCysticercosisEnergy MetabolismFemaleGlucoseHost-Parasite InteractionsKetoglutaric AcidsLactic AcidMiceMice, Inbred BALB CNitro CompoundsTaeniaThiazolesAnticestodal AgentsGlucoseKetoglutaric AcidsLactic AcidnitazoxanideNitro CompoundsThiazolesEnergetic metabolismIn vivo treatmentLactic fermentationNitazoxanideProtein catabolismTaenia crassiceps

Identifiers

PMID28914356
OpenAlexW2756049038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.