ArticleThe Journal of membrane biology2017
Quantification of the Intracellular Life Time of Water Molecules to Measure Transport Rates of Human Aquaglyceroporins.
Article in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism.Nature communications · 2025Article
- Article
- Molecular basis for human aquaporin inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The intracellular helical bundle of human glucose transporter GLUT4 is important for complex formation with ASPL.FEBS open bio · 2023Article
- Cryo-EM structure supports a role of AQP7 as a junction protein.Nature communications · 2023Article
- Aquaporins: New players in breast cancer progression and treatment response.Frontiers in oncology · 2022Review
- Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol.RSC advances · 2020Article
- Article
- INDIANA: An in-cell diffusion method to characterize the size, abundance and permeability of cells.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3.Biochimica et biophysica acta. Biomembranes · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins. Using a newly established Nuclear Magnetic Resonance approach based on measurement of the intracellular life time of water, we propose that human aquaglyceroporins are poor facilitators of water and that the water transport efficiency is similar to that of passive diffusion across native cell membranes. This is distinctly different from glycerol and arsenic trioxide, where high glycerol transport efficiency was recorded.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.