ArticleActa orthopaedica2018
Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients.
Article in Acta orthopaedica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Dynamic distribution of systemically administered antibiotics in orthopeadically relevant target tissues and settings.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2024Pooled it
- Quantification of Vancomycin and Clindamycin in Synovial Tissue and Bone Using Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry.Therapeutic drug monitoring · 2026Article
- High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis.Frontiers in pharmacology · 2025Article
- Efficacy and safety of vancomycin for local application in the prevention of surgical site infection after joint arthroplasty: a systematic review and meta-analysis.EFORT open reviews · 2024Article
- Off-Label Use of Dalbavancin for Sequential Treatment of Spondylodiscitis by Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Evaluation of Vancomycin Accumulation in Patients With Obesity.Open forum infectious diseases · 2022Article
- Tissue Penetration of Antimicrobials in Intensive Care Unit Patients: A Systematic Review-Part I.Antibiotics (Basel, Switzerland) · 2022Review
- Orthopaedic Implant-Associated Staphylococcal Infections: A Critical Reappraisal of Unmet Clinical Needs Associated with the Implementation of the Best Antibiotic Choice.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- High Cefuroxime Concentrations and Long Elimination in an Orthopaedic Surgical Deadspace-A Microdialysis Porcine Study.Antibiotics (Basel, Switzerland) · 2022Article
- Predicting Antimicrobial Activity at the Target Site: Pharmacokinetic/Pharmacodynamic Indices versus Time-Kill Approaches.Antibiotics (Basel, Switzerland) · 2021Review
- Vancomycin bone and tissue concentrations following tibial intraosseous administration - evaluated in a porcine model.Journal of bone and joint infection · 2021Article
- Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration.Bone & joint research · 2021Article
- Article
- The combination of silver-containing hydroxyapatite coating and vancomycin has a synergistic antibacterial effect on methicillin-resistantBone & joint research · 2020Article
- Single-dose pharmacokinetics of meropenem in porcine cancellous bone determined by microdialysis: An animal study.Bone & joint research · 2019Article
- Can systemically administered antibiotics be detected in wound tissues and surfaces under negative pressure wound therapy?International wound journal · 2019Article
- Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study.Acta orthopaedica · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perioperative antimicrobial prophylaxis. Studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. We assessed single-dose plasma, subcutaneous adipose tissue (SCT) and bone concentrations of vancomycin using microdialysis in male patients undergoing total knee replacement. Methods - 1,000 mg of vancomycin was administered postoperatively intravenously over 100 minutes to 10 male patients undergoing primary total knee replacement. Vancomycin concentrations in plasma, SCT, cancellous, and cortical bone were measured over the following 8 hours. Microdialysis was applied for sampling in solid tissues. Results - For all solid tissues, tissue penetration of vancomycin was significantly impaired. The time to a mean clinically relevant minimal inhibitory concentration (MIC) of 2 mg/L was 3, 36, 27, and 110 min for plasma, SCT, cancellous, and cortical bone, respectively. As opposed to the other compartments, a mean MIC of 4 mg/L could not be reached in cortical bone. The area under the concentration-time curve from 0 to the last measured value and peak drug concentrations (C
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Registered trials
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