ArticleRespirology (Carlton, Vic.)2018
Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.
Article in Respirology (Carlton, Vic.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05017519 (Epidemiology and Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus in Children and Elderly), which is not on this map. Cited by 41 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology and Transmission of Streptococcus Pneumoniae and Respiratory Syncytial Virus in Children and Elderly: a Household-based Prospective Cohort Study
Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- An Appraisal of the Potential Downstream Benefits of RSV Vaccination in Older Adults.Reviews in medical virology · 2026Review
- RSV-NTHi Co-Infection Skews Host Immunity by Suppressing Type I IFN Responses and Enhancing Pro-Inflammatory Responses.Pathogens (Basel, Switzerland) · 2026Article
- Article
- Characteristics ofFrontiers in pediatrics · 2026Article
- Respiratory potentially pathogenic bacteria are associated with increased disease severity in neonates with respiratory syncytial virus infection.BMC infectious diseases · 2025Article
- Nasopharyngeal carriage of Streptococcus pneumoniae among Brazilian children: Interplay with viral co-infection.PloS one · 2025Article
- Molecular epidemiology of influenza, respiratory syncytial virus, SARS-CoV-2, other respiratory viruses and bacteria among children 0-2-year-olds in West Bengal: a one-year influenza-like illness surveillance study (2022-2023).Frontiers in epidemiology · 2025Article
- The respiratory microbiome is linked to the severity of RSV infections and the persistence of symptoms in children.Cell reports. Medicine · 2024Article
- Effect of respiratory microflorae colonization on short and long-time outcomes of respiratory syncytial virus infection in children: A scoping review.Pediatric discovery · 2024Review
- Severe respiratory syncytial virus disease.Journal of intensive medicine · 2024Review
- High burden of viruses and bacterial pathobionts drives heightened nasal innate immunity in children.The Journal of experimental medicine · 2024Article
- A Review of the Impact of Streptococcal Infections and Antimicrobial Resistance on Human Health.Antibiotics (Basel, Switzerland) · 2024Review
- Pneumococcal colonization and coinfecting respiratory viruses in children under 5 years in Addis Ababa, Ethiopia: a prospective case-control study.Scientific reports · 2024Article
- Clinical Presentation and Co-Detection of Respiratory Pathogens in Children Under 5 Years with Non-COVID-19 Bacterial and Viral Respiratory Tract Infections: A Prospective Study in Białystok, Poland (2021-2022).Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Childhood respiratory viral infections and the microbiome.The Journal of allergy and clinical immunology · 2023Review
- Epigenome-wide association analysis of infant bronchiolitis severity: a multicenter prospective cohort study.Nature communications · 2023Article
- Investigating the outcomes of virus coinfection within and across host species.PLoS pathogens · 2023Article
- Influence of Sex on Respiratory Syncytial Virus Genotype Infection Frequency and Nasopharyngeal Microbiome.Journal of virology · 2023Article
- Controlled Human Infection Models To Accelerate Vaccine Development.Clinical microbiology reviews · 2022Review
- Integrated relationship of nasopharyngeal airway host response and microbiome associates with bronchiolitis severity.Nature communications · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveRespiratory syncytial virus (RSV) is the most significant cause of acute respiratory infection (ARI) in early life. RSV and other respiratory viruses are known to stimulate substantial outgrowth of potentially pathogenic bacteria in the upper airways of young children. However, the clinical significance of interactions between viruses and bacteria is currently unclear. The present study aimed to clarify the effect of viral and bacterial co-detections on disease severity during paediatric ARI.
methodsNasopharyngeal aspirates from children under 2 years of age presenting with ARI to the emergency department were screened by quantitative PCR for 17 respiratory viruses and the bacterial pathogens Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Associations between pathogen detection and clinical measures of disease severity were investigated.
resultsRSV was the most common virus detected, present in 29 of 58 samples from children with ARI (50%). Detection of S. pneumoniae was significantly more frequent during RSV infections compared to other respiratory viruses (adjusted effect size: 1.8, P: 0.03), and co-detection of both pathogens was associated with higher clinical disease severity scores (adjusted effect size: 1.2, P: 0.03).
conclusionCo-detection of RSV and S. pneumoniae in the nasopharynx was associated with more severe ARI, suggesting that S. pneumoniae colonization plays a pathogenic role in young children.
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