ArticleBrain imaging and behavior2019
Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology.
Article in Brain imaging and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of online tDCS to left somatomotor cortex on neuropsychiatric symptoms among older adults at risk for dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Trial
- Amygdalar Pattern Similarity to Negative and Neutral Images, Ratings of the Images, and PET-Measured Amyloid and Tau Levels in Older Adults Without Dementia.Affective science · 2026Article
- The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective.Neuron · 2026Review
- Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid.Alzheimer's research & therapy · 2026Article
- Neural circuit mechanisms of epilepsy: Maintenance of homeostasis at the cellular, synaptic, and neurotransmitter levels.Neural regeneration research · 2026Article
- Neuropsychiatric symptoms in Alzheimer's disease: Past, present, and future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology-Based Functional Connectivity Analysis.Brain and behavior · 2025Article
- Mapping the Neuropsychiatric Symptoms in Alzheimer's Disease Using Biomarkers, Cognitive Abilities, and Personality Traits: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Profiles of brain topology for dual-functional stability in old age.GeroScience · 2025Article
- Salience network segregation mediates the effect of tau pathology on mild behavioral impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Beyond memory impairment: the complex phenotypic landscape of Alzheimer's disease.Trends in molecular medicine · 2024Review
- Salience Network Segregation Mediates the Effect of Tau Pathology on Mild Behavioral Impairment.medRxiv : the preprint server for health sciences · 2024Article
- Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease.Human brain mapping · 2023Article
- Mesoscopic Mapping of Visual Pathway in a Female 5XFAD Mouse Model of Alzheimer's Disease.Cells · 2022Article
- Alteration of Neural Pathways and Its Implications in Alzheimer's Disease.Biomedicines · 2022Review
- Article
- Divergent patterns of cognitive deficits and structural brain alterations between older adults in mixed-sex and same-sex relationships.Frontiers in human neuroscience · 2022Article
- Neural Correlates of Mild Behavioral Impairment: A Functional Brain Connectivity Study Using Resting-State Functional Magnetic Resonance Imaging.Journal of Alzheimer's disease : JAD · 2021Article
- Evaluating the reliability of neurocognitive biomarkers of neurodegenerative diseases across countries: A machine learning approach.NeuroImage · 2020Article
- An update on magnetic resonance imaging markers in AD.Therapeutic advances in neurological disorders · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD pathology. Here, we explored the neural circuits of NPS in AD-associated neurodegeneration using multivariate pattern analysis (MVPA) of resting-state functional MRI data. Data from 98 subjects (70 amnestic mild cognitive impairment and 28 AD subjects) were obtained. The top 10 regions differentiating symptom presence across NPS were identified, which were mostly the fronto-limbic regions (medial prefrontal cortex, caudate, etc.). These 10 regions' functional connectivity classified symptomatic subjects across individual NPS at 69.46-81.27%, and predicted multiple NPS (indexed by Neuropsychiatric Symptom Questionnaire-Inventory) and AD pathology (indexed by baseline and change of beta-amyloid/pTau ratio) all above 70%. Our findings suggest a fronto-limbic dominated neural circuit that links multiple NPS and AD pathology. With further examination of the structural and pathological changes within the circuit, the circuit may shed light on linking behavioral disturbances with AD-associated neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.