Evidence map›Paper›PMID 28913665›Full record

ReviewCellular and molecular life sciences : CMLS2018

Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases.

Yanhan Dong, Cuiyun Liu, Yanfang Zhao, Murugavel Ponnusamy, Peifeng Li, Kun Wang

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Molecular mechanisms and intervention approaches of heart failure (Review).International journal of molecular medicine · 2025
    Review
  4. Article
  5. Review
  6. Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Role of Circular RNAs in the Pathogenesis of Cardiovascular Disease.Journal of cardiovascular translational research · 2020
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy.International journal of biological sciences · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yanhan DongInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China.
Cuiyun LiuInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China.
Yanfang ZhaoInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China.
Murugavel PonnusamyInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China.
Peifeng LiInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China. peifli@qdu.edu.cn.
Kun WangInstitute for Translational Medicine, Qingdao University, Deng Zhou Road 38, Qingdao, 266021, China. wangk696@qdu.edu.cn.
Qingdao University · CN

Funding

Applied Basic Research Programs of Qingdao, China 17-1-1-46-jchNational Natural Science Foundation of China 31430041National Natural Science Foundation of China (CN) 81522005Natural Science Foundation of China 81470522Shandong Provincial Natural Science Foundation, China ZR2016CQ31
6 · The paper itself

Abstract

Loss of functional cardiomyocytes is a major underlying mechanism for myocardial remodeling and heart diseases, due to the limited regenerative capacity of adult myocardium. Apoptosis, programmed necrosis, and autophagy contribute to loss of cardiac myocytes that control the balance of cardiac cell death and cell survival through multiple intricate signaling pathways. In recent years, non-coding RNAs (ncRNAs) have received much attention to uncover their roles in cell death of cardiovascular diseases, such as myocardial infarction, cardiac hypertrophy, and heart failure. In addition, based on the view that mitochondrial morphology is linked to three types of cell death, ncRNAs are able to regulate mitochondrial fission/fusion of cardiomyocytes by targeting genes involved in cell death pathways. This review focuses on recent progress regarding the complex relationship between apoptosis/necrosis/autophagy and ncRNAs in the context of myocardial cell death in response to stress. This review also provides insight into the treatment for heart diseases that will guide novel therapies in the future.

Indexed as

AnimalsApoptosisAutophagyCardiovascular DiseasesGene Expression RegulationHumansModels, GeneticMyocytes, CardiacNecrosisRNA, UntranslatedRNA, UntranslatedApoptosisAutophagyCardiomyocyte deathHeart diseasesmiRNAsNecrosis

Identifiers

PMID28913665
PMCPMC11105653
OpenAlexW2754045273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.