SynthesisEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2017
Local analgesia in paediatric dentistry: a systematic review of techniques and pharmacologic agents.
Synthesis in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Clinical and radiographic outcomes of laser pulpotomy in vital primary teeth: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2018Pooled it
- Best clinical practice guidance for local analgesia in paediatric dentistry: an EAPD policy document.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2017Guideline
- Comparative evaluation of anesthetic delivery systems on pain, anxiety, and physiological responses in pediatric dental patients: A randomized clinical trial.Scientific reports · 2026Trial
- The effect of needle demonstration during local anaesthesia on the child's dental fear, pain perception and behaviour: a randomised controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Trial
- Comparative study of articaine 4% versus lidocaine 2% in the local anesthesia of permanent mandibular first molars affected by MIH: a randomized controlled trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Trial
- Comparison of two behavior management techniques used during mandibular block anesthesia among preschool children: a randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- Comparative evaluation of the anesthetic efficacy of 4% buffered articaine versus 2% un-buffered lidocaine for dental injections in children: a double-blind randomized parallel group control trial.Journal of dental anesthesia and pain medicine · 2026Article
- Effectiveness of buffered local anesthetic solutions in pediatric nerve blocks and infiltration anesthesia: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2026Review
- Assessing the Impact of Green Tea Extract on Postoperative Pain Control in Children Undergoing Orthodontic Extractions: A Split-mouth, Randomized, Controlled, Double-blinded Trial.International journal of clinical pediatric dentistry · 2025Article
- Comparison of different techniques used for inferior alveolar nerve block anaesthesia regarding the pain caused in cooperative children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Swiss paediatric dentists' preferences and experience on the use of articaine and other local/topical anaesthetics.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Application of multi-disciplinary team nursing model enhances recovery after surgery for total hip arthroplasty and total knee arthroplasty.American journal of translational research · 2024Article
- Analyzing facial action units in children to differentiate genuine and fake pain during inferior alveolar nerve block: a cross-sectional study.Scientific reports · 2023Article
- Efficacy of inferior alveolar nerve block and intraligamentary anesthesia in the extraction of primary mandibular molars: A randomized controlled clinical trial.The Saudi dental journal · 2023Article
- Post-operative discomforts in children after extraction of primary teeth.Clinical and experimental dental research · 2020Observational
- Postoperative pain profile in 10-15-year-olds after bilateral extraction of maxillary premolars.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the evidence supporting effects and adverse effects of local analgesia using different pharmacological agents and injection techniques during dental treatment in children and adolescents aged 3-19 years.
methodsA systematic literature search of databases including PubMed, Cochrane, and Scopus was conducted in November 2016. The PRISMA-statement was followed. Two review authors independently assessed the selected randomised control trials for risk of bias and quality.
results725 scientific papers were identified. 89 papers were identified to be read in full text of which 80 were excluded. Finally, 9 papers were evaluated for quality and risk of bias. Many of the included papers had methodological shortcomings affecting the possibility to draw conclusions. Information about ethical clearance and consent were missing in some of the included papers. No alarming adverse effects were identified. One study was assessed as having low risk of bias. This reported inferior alveolar nerve block to be more effective than buccal infiltration for dental treatment of mandibular molars, while no differences were found regarding pharmacological agents.
conclusionsAt present, there is insufficient evidence in support of any pharmacologic agent or injection technique as being superior compared to others. There is a need for more rigorous studies which also handle the ethical issues of including children in potentially painful studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.