Evidence map›Paper›PMID 28913643›Full record

Trial reportPsychopharmacology2017

Does oxytocin lead to emotional interference during a working memory paradigm?

Marieke S Tollenaar, M Ruissen, B M Elzinga, E R A de Bruijn

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marieke S TollenaarInstitute of Psychology, Department of Clinical Psychology, Leiden University and Leiden Institute for Brain and Cognition, PO Box 9555, 2300 RB, Leiden, The Netherlands. m.s.tollenaar@fsw.leidenuniv.nl.
M RuissenInstitute of Psychology, Department of Clinical Psychology, Leiden University and Leiden Institute for Brain and Cognition, PO Box 9555, 2300 RB, Leiden, The Netherlands.
B M ElzingaInstitute of Psychology, Department of Clinical Psychology, Leiden University and Leiden Institute for Brain and Cognition, PO Box 9555, 2300 RB, Leiden, The Netherlands.
E R A de BruijnInstitute of Psychology, Department of Clinical Psychology, Leiden University and Leiden Institute for Brain and Cognition, PO Box 9555, 2300 RB, Leiden, The Netherlands.
Leiden University · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 452-12-005
6 · The paper itself

Abstract

backgroundOxytocin administration may increase attention to emotional information. We hypothesized that this augmented emotional processing might in turn lead to interference on concurrent cognitive tasks. To test this hypothesis, we examined whether oxytocin administration would lead to heightened emotional interference during a working memory paradigm. Additionally, moderating effects of childhood maltreatment were explored.

methodsSeventy-eight healthy males received 24 IU of intranasal oxytocin or placebo in a randomized placebo-controlled double-blind between-subjects study. A working memory task was performed during which neutral, positive, and negative distractors were presented.

resultsThe main outcome observed was that oxytocin did not enhance interference by emotional information during the working memory task. There was a non-significant trend for oxytocin to slow down performance irrespective of distractor valence, while accuracy was unaffected. Exploratory analyses showed that childhood maltreatment was related to lower overall accuracy, but in the placebo condition only. However, the maltreated group sample size was very small precluding any conclusions on its moderating effect.

conclusionsDespite oxytocin's previously proposed role in enhanced emotional processing, no proof was found that this would lead to reduced performance on a concurrent cognitive task. The routes by which oxytocin exerts its effects on cognitive and social-emotional processes remain to be fully elucidated.

Indexed as

Facial ExpressionAdministration, IntranasalAdolescentAdultAttentionDouble-Blind MethodEmotionsHumansMaleMemory, Short-TermOxytocicsOxytocinReaction TimeYoung AdultOxytocicsOxytocinChildhood maltreatmentDistractorEmotionInterferenceOxytocinWorking memory

Identifiers

PMID28913643
PMCPMC5691090
OpenAlexW2755673558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.