ArticleBrain structure & function2018
The mediating role of cortical thickness and gray matter volume on sleep slow-wave activity during adolescence.
Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Structural Alterations in Large-scale Brain Networks and Their Relationship with Sleep Disturbances in the Adolescent Population.Scientific reports · 2020Trial
- Morphometric alterations of the gray matter of the frontal lobe during childhood in healthy children born prematurely. Repercussions of foetal and postnatal growth restriction.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
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- Sleep Physiology and Neurocognition Among Adolescents With Attention-Deficit/Hyperactivity Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Observational
- Targeted Sleep Enhancement Reduces Residual Anxiety Symptoms in Peri-Adolescents Previously Treated for Anxiety Disorders.Behavior therapy · 2025Article
- Article
- The Role of Sleep for Age-Related Differences in Neurobehavioral Performance.Life (Basel, Switzerland) · 2024Article
- Association between cortical thickness and cognitive ability in very preterm school-age children.Scientific reports · 2024Article
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- Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities.CNS & neurological disorders drug targets · 2024Review
- Age-associated sleep spindle characteristics in Duchenne muscular dystrophy.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Effects of emerging alcohol use on developmental trajectories of functional sleep measures in adolescents.Sleep · 2023Article
- The sleep and wake electroencephalogram over the lifespan.Neurobiology of aging · 2023Article
- Wearable and mobile technology to characterize daily patterns of sleep, stress, presleep worry, and mood in adolescent insomnia.Sleep health · 2023Article
- Sex differences in predictors and regional patterns of brain age gap estimates.Human brain mapping · 2022Article
- Sleep to Internalizing Pathway in Young Adolescents (SIPYA): A proposed neurodevelopmental model.Neuroscience and biobehavioral reviews · 2022Review
- Effect of detoxification on N3 sleep correlates with brain functional but not structural changes in alcohol use disorder.Drug and alcohol dependence · 2022Article
- Features of the EEG Pattern of Sleep Spindles and Its Diagnostic Significance in Ontogeny.Bulletin of experimental biology and medicine · 2022Review
- Article
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
During the course of adolescence, reductions occur in cortical thickness and gray matter (GM) volume, along with a 65% reduction in slow-wave (delta) activity during sleep (SWA) but empirical data linking these structural brain and functional sleep differences, is lacking. Here, we investigated specifically whether age-related differences in cortical thickness and GM volume and cortical thickness accounted for the typical age-related difference in slow-wave (delta) activity (SWA) during sleep. 132 healthy participants (age 12-21 years) from the National Consortium on Alcohol and NeuroDevelopment in Adolescence study were included in this cross-sectional analysis of baseline polysomnographic, electroencephalographic, and magnetic resonance imaging data. By applying mediation models, we identified a large, direct effect of age on SWA in adolescents, which explained 45% of the variance in ultra-SWA (0.3-1 Hz) and 52% of the variance in delta-SWA (1 to <4 Hz), where SWA was lower in older adolescents, as has been reported previously. In addition, we provide evidence that the structure of several, predominantly frontal, and parietal brain regions, partially mediated this direct age effect, models including measures of brain structure explained an additional 3-9% of the variance in ultra-SWA and 4-5% of the variance in delta-SWA, with no differences between sexes. Replacing age with pubertal status in models produced similar results. As reductions in GM volume and cortical thickness likely indicate synaptic pruning and myelination, these results suggest that diminished SWA in older, more mature adolescents may largely be driven by such processes within a number of frontal and parietal brain regions.
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