Evidence map›Paper›PMID 28913561›Full record

ArticleJournal of molecular modeling2017

Conformational rearrangement of 1,2-d(GG) intrastrand cis-diammineplatinum crosslinked DNA is driven by counter-ion penetration within the minor groove of the modified site.

Tsvetan G Gantchev, Peicho St Petkov, Darel J Hunting

Abstract read
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In one paragraph

Article in Journal of molecular modeling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tsvetan G GantchevDepartment of Nuclear Medicine & Radiobiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada. tsvetan.gantchev@usherbrooke.ca.
Peicho St PetkovDepartment of Atomic Physics, Faculty of Physics, Sofia University, 5 James Bourchier Blvd., 1164, Sofia, Bulgaria.
Darel J HuntingDepartment of Nuclear Medicine & Radiobiology, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The major structural aberrations of DNA induced by a cis-diammineplatinum (II) 1,2-d(GG) intrastrand cross-link (CPT) have been known for decades. To gain deeper insights into the structural dynamics of the sequence-dependent DNA distortions adjacent to the CPT adduct, we employed molecular modeling and molecular dynamics (MD) simulations. The structural dynamics of native (N-DNA) and cisPt 1,2-d(GG) crosslinked (CPT-DNA) in the form of symmetric 36 nt d(G

Indexed as

Antineoplastic AgentsCisplatinCross-Linking ReagentsDNADNA AdductsDNA DamageHumansIonsModels, MolecularMolecular Dynamics SimulationNuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationOligonucleotidesAntineoplastic AgentsCisplatinCross-Linking ReagentsDNADNA AdductsIonsOligonucleotidesCisplatinConformational rearrangement, counter ion and water dynamicsDNA dynamic structureIntrastrand crosslinkMolecular dynamicsMolecular modeling

Identifiers

PMID28913561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.