Evidence map›Paper›PMID 28913556›Full record

ArticleEuropean journal of nutrition2018

High-dose vitamin D

Nina Friis Bak, M Bendix, S Hald, L Reinert, M K Magnusson, J Agnholt

Abstract read
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In one paragraph

Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Allergic diseases in infancy II-oral tolerance and its failure.The World Allergy Organization journal · 2021
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nina Friis BakDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Noerrebrogade 44 Building 1C Ground Floor, Aarhus C, Denmark. ninbak@rm.dk.ORCID http://orcid.org/0000-0002-9714-0063
M BendixDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Noerrebrogade 44 Building 1C Ground Floor, Aarhus C, Denmark.
S HaldDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Noerrebrogade 44 Building 1C Ground Floor, Aarhus C, Denmark.
L ReinertDepartment of Biomedicine, Aarhus University, Aarhus C, Denmark.
M K MagnussonDepartment of Microbiology and Immunology, Institute for Biomedicine, University of Gothenburg, Gothenburg, Sweden.
J AgnholtDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Noerrebrogade 44 Building 1C Ground Floor, Aarhus C, Denmark.
Aarhus University Hospital · DKAarhus University · DKUniversity of Gothenburg · SE

Funding

Knud and Edith Eriksens Memorial fund 62786
6 · The paper itself

Abstract

purposeVitamin D may induce tolerance in the intestinal immune system and has been shown to regulate the phenotype of tolerogenic intestinal dendritic cells (DCs) in vitro. It is unknown whether vitamin D supplementation affects human intestinal DCs in vivo, and we aimed to investigate the tolerability and effect on intestinal CD103

methodsTen healthy subjects received a total of 480,000 IU oral vitamin D

resultsNo hypercalcemia or other adverse events occurred in the test subjects. Vitamin D decreased the number of CD103

conclusionHigh-dose vitamin D supplementation is well tolerated by healthy subjects and has a direct effect on the CD103

Indexed as

CholecalciferolColonDendritic CellsDose-Response Relationship, DrugHealthy VolunteersHumansIntestinal MucosaT-Lymphocytes, RegulatoryCholecalciferolCD103+ dendritic cellsIntestinal immune systemPD-L1Vitamin D

Identifiers

PMID28913556
OpenAlexW2756172142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.