Evidence map›Paper›PMID 28913547›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2017

Probucol prevents the attenuation of β

Asami Mori, Kentaro Higashi, Shun Wakao, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Pirfenidone Is a Vasodilator: Involvement of KFrontiers in pharmacology · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Asami MoriDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Kentaro HigashiDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Shun WakaoDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Kenji SakamotoDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Kunio IshiiDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
Tsutomu NakaharaDepartment of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. nakaharat@pharm.kitasato-u.ac.jp.
Kitasato University · JP

Funding

JSPS KAKENHI 15K08242JSPS KAKENHI 16K08554JSPS KAKENHI 26460103
6 · The paper itself

Abstract

Probucol is an antihyperlipidemic drug with potent antioxidant properties. Oxidative stress plays an important role in the pathogenesis of diabetic retinopathy. In this study, we aimed to investigate the protective effects of probucol against diabetes-induced retinal vascular dysfunction in a rat model of diabetes. Diabetes was induced by a combination of streptozotocin treatment and D-glucose feeding, and retinal vasodilator responses were assessed by measuring the diameter of retinal arterioles. The vasodilator effect of salbutamol, a β

Indexed as

Adrenergic beta-2 Receptor AgonistsAlbuterolAnimalsAnticholesteremic AgentsArteriolesBlood GlucoseDiabetes Mellitus, ExperimentalDiabetic RetinopathyMalePeptidesPotassium Channel BlockersProbucolRatsRats, WistarReceptors, Adrenergic, beta-2Retinal ArteryAdrenergic beta-2 Receptor AgonistsAlbuterolAnticholesteremic AgentsBlood GlucoseiberiotoxinPeptidesPotassium Channel BlockersProbucolReceptors, Adrenergic, beta-2HyperglycemiaLarge-conductance Ca2+-activated K+ channelsOxidative stressRetinal circulationβ2-adrenoceptor

Identifiers

PMID28913547
OpenAlexW2754611118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.