ArticleJournal of occupational medicine and toxicology (London, England)2017
Can yesterday's smoking research inform today's shiftwork research? Epistemological consequences for exposures and doses due to circadian disruption at and off work.
Article in Journal of occupational medicine and toxicology (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis.International journal of molecular sciences · 2023Review
- Role of Melatonin in Cancer: Effect on Clock Genes.International journal of molecular sciences · 2023Review
- Sleep Irregularity and Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis.Journal of the American College of Cardiology · 2020Article
- The riddle of shiftwork and disturbed chronobiology: a case study of landmark smoking data demonstrates fallacies of not considering the ubiquity of an exposure.Journal of occupational medicine and toxicology (London, England) · 2020Article
- Hypothesis: ubiquitous circadian disruption can cause cancer.European journal of epidemiology · 2019Article
- IARC 2019: "Night shift work" is probably carcinogenic: What about disturbed chronobiology in all walks of life?Journal of occupational medicine and toxicology (London, England) · 2019Article
- Ticking time bomb? High time for chronobiological research.EMBO reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1950, landmark epidemiology studies by Wynder & Graham and Doll & Hill contributed to identifying smoking as a potent carcinogen. In 2007, IARC classified shiftwork involving circadian disruption (CD) as probably carcinogenic; however, epidemiological evidence in regards to the carcinogenicity of shiftwork that involves nightwork is conflicting. We hypothesize that shiftwork research is lacking chronobiological and methodological rigor and that lessons can be learned from comparison with smoking research. Herein, we provide a factual view at, and a fictional case study of, 1940s smoking research which serves as an analogy for current shiftwork research dilemmas. This analogy takes the form of limiting counting cigarettes to a particular time window (i.e. at work) rather than assessing exposures to, and doses of, accumulated smoking over 24 h, highlighting the importance of exposure and dose. Simply put, smoking insights could have been delayed or even disallowed. In conclusion, CD may be similar to smoking insofar as for quantitative measures of cumulative doses, exposures both at and off work may have to be considered. Future work must explore whether such similarity factually exists and whether CD is a cancer hazard in IARC terms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.