Evidence map›Paper›PMID 28912665›Full record

ArticleSarcoma2017

Multimodal Approach of Pulmonary Artery Intimal Sarcoma: A Single-Institution Experience.

S Secondino, V Grazioli, F Valentino, M Pin, A Pagani, A Sciortino, C Klersy, M G Callegari, P Morbini, R Dore and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Sarcoma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Pulmonary Artery Sarcoma Study: A Multi-Centre European Society of Thoracic Surgeons Working Group Evaluating Diagnosis, Treatment, and Outcomes.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026
    Article
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  7. Pulmonary artery intimal sarcoma: Case report of a patient managed with multimodality treatment and a comprehensive literature review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

S SecondinoDivision of Medical Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0001-8839-139X
V GrazioliCardiothoracic Surgery Department, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
F ValentinoDivision of Medical Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
M PinCardiothoracic Surgery Department, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
A PaganiDivision of Medical Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
A SciortinoCardiothoracic Surgery Department, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
C KlersyService of Biometry & Statistics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
M G CallegariUnit of Pulmonary Rehabilitation, ICS Maugeri Istituto Scientifico di Montescano, Pavia, Italy.
P MorbiniUnit of Pathology, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
R DoreDivision of Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
M PaulliUnit of Pathology, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
P PedrazzoliDivision of Medical Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0002-9419-7160
A M D'arminiCardiothoracic Surgery Department, Fondazione IRCCS Policlinico San Matteo and Pavia University School of Medicine, Pavia, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico San Matteo Fondazione · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPulmonary artery sarcoma (PAS) is a rare tumor, whose therapeutic approach is mainly based on surgery, either pneumonectomy or pulmonary endarterectomy (PEA). The prognosis reported in published series is very poor, with survival of 1.5 months without any kind of treatment. PATIENTS AND

methodsFrom January 2010 to January 2016, 1027 patients were referred to our hospital for symptoms of acute or chronic pulmonary thromboembolic disease. Twelve patients having a confirmed diagnosis of PAS underwent PEA. Median age was 64.5 years. Most patients had a long history of symptoms, having a median time of 7.5 months from onset of symptoms to surgery.

resultsFollowing PEA and cardiopulmonary rehabilitation, 10 patients received conventional chemotherapy with doxorubicin and ifosfamide, starting at a median of 42 days from surgery. Four patients also received radiotherapy. Four patients have died due to disease progression, while 7 are still alive, with 5 being disease-free at 4-55+ months from diagnosis.

conclusionsIn patients with PAS, a multimodal approach including PEA, CT, and RT is feasible but it should be evaluated individually, according to the tumor extension and the patient's clinical condition. Apart from improving quality of life mainly by reducing or delaying symptoms due to PH, it may improve life expectancy.

Identifiers

PMID28912665
PMCPMC5585613
OpenAlexW2745551380

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.