ArticleScientific reports2017
Oxytocin Receptor Polymorphisms are Differentially Associated with Social Abilities across Neurodevelopmental Disorders.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Systematic Review of Literature on Single-Nucleotide Polymorphisms Within the Oxytocin and Vasopressin Receptor Genes in the Development of Social Cognition Dysfunctions in Individuals Suffering From Autism Spectrum Disorder.Frontiers in psychiatry · 2019Pooled it
- Meta-Analysis of the RDoC Social Processing Domain across Units of Analysis in Children and Adolescents.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2021Trial
- LinkedbioRxiv : the preprint server for biology · 2025Article
- Oxytocin Receptor Single-Nucleotide Polymorphisms Are Related to Maternal-Infant Co-Occupation and Infant Sensory Processing.Children (Basel, Switzerland) · 2024Article
- Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype.Translational psychiatry · 2024Article
- Article
- Prenatal allergic inflammation in rats confers sex-specific alterations to oxytocin and vasopressin innervation in social brain regions.Hormones and behavior · 2024Article
- The Role of Oxytocin in Alzheimer's Disease and Its Relationship with Social Interaction.Cells · 2023Review
- A Scientometric Review of Infant Cry and Caregiver Responsiveness: Literature Trends and Research Gaps over 60 Years of Developmental Study.Children (Basel, Switzerland) · 2023Review
- Roles of the Oxytocin Receptor (OXTR) in Human Diseases.International journal of molecular sciences · 2023Review
- Autism Spectrum Disorder: Neurodevelopmental Risk Factors, Biological Mechanism, and Precision Therapy.International journal of molecular sciences · 2023Review
- Oxytocin and vasotocin receptor variation and the evolution of human prosociality.Comprehensive psychoneuroendocrinology · 2022Article
- Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications.Signal transduction and targeted therapy · 2022Review
- Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank.Translational psychiatry · 2021Article
- DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders.Journal of autism and developmental disorders · 2021Article
- Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders.Brain sciences · 2020Review
- Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders.Frontiers in psychiatry · 2020Review
- Exploring the Neural Structures Underlying the Procedural Memory Network as Predictors of Language Ability in Children and Adolescents With Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder.Frontiers in human neuroscience · 2020Article
- Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin is a pituitary neuropeptide that affects social behaviour. Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) have been shown to explain some variability in social abilities in control populations. Whether these variants similarly contribute to the severity of social deficits experienced by children with neurodevelopmental disorders is unclear. Social abilities were assessed in a group of children with autism spectrum disorder (ASD, n = 341) or attention deficit hyperactivity disorder (ADHD, n = 276) using two established social measures. Scores were compared by OXTR genotype (rs53576, rs237887, rs13316193, rs2254298). Unexpectedly, the two most frequently studied OXTR SNPs in the general population (rs53576 and rs2254298) were associated with an increased severity of social deficits in ASD (p < 0.0001 and p = 0.0005), yet fewer social deficits in ADHD (p = 0.007 and p < 0.0001). We conclude that these genetic modifier alleles are not inherently risk-conferring with respect to their impact on social abilities; molecular investigations are greatly needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.