ArticleArteriosclerosis, thrombosis, and vascular biology2017
TGFβ (Transforming Growth Factor-β) Blockade Induces a Human-Like Disease in a Nondissecting Mouse Model of Abdominal Aortic Aneurysm.
Open access · greenAbstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 90 citations in OpenAlex.
- The Role of miR-501-3p in Abdominal Aortic Aneurysm Progression: A Pilot Study.Journal of cardiovascular translational research · 2026Article
- Synergistic elastase and papain injury drives abdominal aortic aneurysm formation and rupture in mice.Communications medicine · 2026Article
- Role of Extracellular Vesicles in Abdominal Aortic Aneurysm: Pathophysiology, Biomarkers, and Therapeutic Potentials.International journal of molecular sciences · 2026Review
- Matrix metalloproteinase-12 in arterial diseases: context-dependent mechanisms of vascular remodeling and therapeutic implications.Frontiers in cardiovascular medicine · 2026Review
- Abdominal Aortic Aneurysm and Liver Fibrosis: Clinical Evidence and Molecular Pathomechanisms.International journal of molecular sciences · 2025Review
- Analysis ofInternational journal of molecular sciences · 2025Article
- Sexual Dimorphism in Abdominal Aortic Aneurysm-Insights from Clinical and Experimental Studies.Journal of vascular diseases · 2025Article
- Augmented expression of superoxide dismutase 2 mitigates progression and rupture of experimental abdominal aortic aneurysm.Theranostics · 2025Article
- Macrophage polarization and metabolic reprogramming in abdominal aortic aneurysm.Immunity, inflammation and disease · 2024Review
- Glucagon-Like Peptide-1 Inhibits the Progression of Abdominal Aortic Aneurysm in Mice: The Earlier, the Better.Cardiovascular drugs and therapy · 2024Article
- Small AAAs: Recommendations for Rodent Model Research for the Identification of Novel Therapeutics.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- SLC44A2 regulates vascular smooth muscle cell phenotypic switching and aortic aneurysm.The Journal of clinical investigation · 2024Article
- Article
- [Development, techniques, and utility of experimental animal models of thoracic and abdominal aortic aneurysms].Archivos de cardiologia de Mexico · 2024Review
- Role of elastic fiber degradation in disease pathogenesis.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- Platelets at the Vessel Wall in Non-Thrombotic Disease.Circulation research · 2023Review
- Specific Overexpression of YAP in Vascular Smooth Muscle Attenuated Abdominal Aortic Aneurysm Formation by Activating Elastic Fiber Assembly via LTBP4.Journal of cardiovascular translational research · 2023Article
- Murine model of elastase-induced proximal thoracic aortic aneurysm through a midline incision in the anterior neck.Frontiers in cardiovascular medicine · 2023Article
- Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.Frontiers in immunology · 2023Article
- The future for the therapeutics of abdominal aortic aneurysm: engineered nanoparticles drug delivery for abdominal aortic aneurysm.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
- Commented on by
Authors and funding
13 authors at 1 institution in 1 country.
Fabien LareyreFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Marc ClémentFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Juliette RaffortFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Stefanie PohlodFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Meghana PatelFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Bruno EspositoFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Leanne MasterFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Alison FiniganFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Marie VandestienneFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Nikolaos StergiopulosFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Soraya TalebFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Bram TrachetFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.).
Ziad MallatFrom the Division of Cardiovascular Medicine, University of Cambridge, UK (F.L., M.C., J.R., M.P., L.M., A.F., Z.M.); Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Institute for Research on Cancer and Aging in Nice, France (F.L., J.R.); University Hospital of Nice, France (F.L, J.R.); Institut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, France (B.E., M.V., S.T., Z.M.); Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Switzerland (S.P., N.S., B.T.); and IBiTech-bioMMeda (Institute Biomedical Technology-Biofluid, Tissue and Solid Mechanics for Medical Applications), Ghent University, Belgium (N.S., B.T.). zm255@medchl.cam.ac.uk.
Institut de Recherche sur le Cancer et le Vieillissement de Nice · FR
Funding
British Heart Foundation RG/15/11/31593
Abstract
objectiveCurrent experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that blockade of TGFβ (transforming growth factor-β) activity-a guardian of vascular integrity and immune homeostasis-would impair vascular healing in models of nondissecting AAA and would lead to sustained aneurysmal growth until rupture. APPROACH AND
resultsHere, we test this hypothesis in the elastase-induced AAA model in mice. We analyze AAA development and progression using ultrasound in vivo, synchrotron-based ultrahigh resolution imaging ex vivo, and a combination of biological, histological, and flow cytometry-based cellular and molecular approaches in vitro. Systemic blockade of TGFβ using a monoclonal antibody induces a transition from a self-contained aortic dilatation to a model of sustained aneurysmal growth, associated with the formation of an intraluminal thrombus. AAA growth is associated with wall disruption but no medial dissection and culminates in fatal transmural aortic wall rupture. TGFβ blockade enhances leukocyte infiltration both in the aortic wall and the intraluminal thrombus and aggravates extracellular matrix degradation. Early blockade of IL-1β or monocyte-dependent responses substantially limits AAA severity. However, blockade of IL-1β after disease initiation has no effect on AAA progression to rupture.
conclusionsEndogenous TGFβ activity is required for the healing of AAA. TGFβ blockade may be harnessed to generate new models of AAA with better relevance to the human disease. We expect that the new models will improve our understanding of the pathophysiology of AAA and will be useful in the identification of new therapeutic targets.
Indexed as
Pancreatic ElastaseAnimalsAntibodies, MonoclonalAorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureApolipoproteins EChemotaxis, LeukocyteDilatation, PathologicDisease Models, AnimalDisease ProgressionExtracellular MatrixInterleukin-1betaKineticsMaleMice, Inbred C57BLAntibodies, MonoclonalApolipoproteins EIL1B protein, mouseInterleukin-1betaPancreatic ElastaseTransforming Growth Factor betaaneurysmanimalshumansimmune systemmodels
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.