Evidence map›Paper›PMID 28912346›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

The Blood Pressure-Lowering Effect of 20-HETE Blockade in

Varunkumar Pandey, Victor Garcia, Ankit Gilani, Priyanka Mishra, Frank Fan Zhang, Mahesh P Paudyal, John R Falck, Alberto Nasjletti, Wen-Hui Wang, Michal Laniado Schwartzman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Urinary βJournal of xenobiotics · 2025
    Article
  4. The CYP/20-HETE/GPR75 axis in hypertension.Advances in pharmacology (San Diego, Calif.) · 2022
    Review
  5. Article
  6. Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  7. Article
  8. High-fat diet-induced obesity and insulin resistance in CYP4a14American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  9. Review
  10. 20-HETE: Hypertension and Beyond.Hypertension (Dallas, Tex. : 1979) · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Varunkumar PandeyDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Victor GarciaDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Ankit GilaniDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Priyanka MishraDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Frank Fan ZhangDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Mahesh P PaudyalDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
John R FalckDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Alberto NasjlettiDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Wen-Hui WangDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.).
Michal Laniado SchwartzmanDepartment of Pharmacology, New York Medical College School of Medicine, Valhalla, New York (V.P., V.G., A.G., P.M., F.F.Z., A.N., W.-H.W., M.L.S.); and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas (M.P.P., J.R.F.) michal_schwartzman@nymc.edu.
New York Medical College · USThe University of Texas Southwestern Medical Center · US

Funding

Vasoregulatory Function of CYP2E1-Derived EicosanoidsP01HL034300 · NHLBI · NEW YORK MEDICAL COLLEGE · PI JIANG, HOULI · 1985 to 2015
$33.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4M
Role of Kir4.1 in Regulating NCC and ROMK in DCTR56DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2021 to 2021
$100k
NHLBI NIH HHS P01 HL034300NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R56 DK054983
6 · The paper itself

Abstract

20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) has been linked to pro-hypertensive and anti-hypertensive actions through its ability to promote vasoconstriction and inhibit Na transport in the ascending limb of the loop of Henle, respectively. In this study, we assessed the effects of 20-HETE blockade on blood pressure, renal hemodynamics, and urinary sodium excretion in

Indexed as

AnimalsAntihypertensive AgentsBlood PressureCytochrome P450 Family 4FemaleGlomerular Filtration RateHydroxyeicosatetraenoic AcidsKidney TubulesMaleMiceMice, KnockoutNatriuresisPolyethylene GlycolsRenal CirculationSiloxanesSodium20-hydroxy-5,8,11,14-eicosatetraenoic acidAntihypertensive AgentsCyp4a14 protein, mouseCytochrome P450 Family 4hexaoxyethylenated trisiloxaneHydroxyeicosatetraenoic AcidsPolyethylene GlycolsSiloxanesSodium

Identifiers

PMID28912346
PMCPMC5698946
OpenAlexW2754053137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.