ArticleEndocrine connections2017
Duration of post-operative hypocortisolism predicts sustained remission after pituitary surgery for Cushing's disease.
Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prediction of remission in cushing's disease using artificial intelligence: A systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Outcomes of pituitary surgery for Cushing's disease: a systematic review and meta-analysis.Pituitary · 2020Pooled it
- Early postoperative LDDST enhances remission prediction beyond morning cortisol in cushing's disease.Pituitary · 2026Article
- A bibliometric analysis of Cushing's disease and magnetic resonance imaging: history, research hotspots, and emerging trends.Quantitative imaging in medicine and surgery · 2025Article
- The CuPeR model: A dynamic online tool for predicting Cushing's disease persistence and recurrence after pituitary surgery.Journal of clinical & translational endocrinology · 2025Article
- The prevalence and predictors of Cushing disease recurrence: a 10-year experience of a pituitary tumor center of excellence.Endocrine · 2025Article
- Cushing syndrome.Nature reviews. Disease primers · 2025Review
- The State of Machine Learning in Outcomes Prediction of Transsphenoidal Surgery: A Systematic Review.Journal of neurological surgery. Part B, Skull base · 2023Article
- Clinical profile and treatment outcomes of patients with ectopic ACTH syndrome compared to Cushing disease: a single-center experience.Endocrine · 2023Observational
- The association of bone mineral density Z-score with the early postoperative remission and characteristics of bone mineral loss in patients with Cushing's disease: a retrospective study.Croatian medical journal · 2022Article
- MRI-negative Cushing's Disease: Management Strategy and Outcomes in 15 Cases Utilizing a Pure Endoscopic Endonasal Approach.BMC endocrine disorders · 2022Article
- Article
- Low but not undetectable early postoperative nadir serum cortisol predicts sustained remission in Cushing's disease.Endocrine oncology (Bristol, England) · 2022Article
- Remission in Cushing's disease is predicted by cortisol burden and its withdrawal following pituitary surgery.Journal of endocrinological investigation · 2021Article
- Morning Serum Cortisol as a Predictor for the HPA Axis Recovery in Cushing's Disease.International journal of endocrinology · 2021Article
- Prediction of recurrence and remission within 3 years in patients with Cushing disease after successful transnasal adenomectomy.Pituitary · 2019Article
- The Utility of Intraoperative Cytological Smear and Frozen Section in the Surgical Management of Patients with Cushing's Disease due to Pituitary Microadenomas.Endocrine pathology · 2019Article
- Outcome of endoscopic vs microsurgical transsphenoidal resection for Cushing's disease.Endocrine connections · 2018Review
- An Integrated Clinical Score to Predict Remission in Cushing's Disease.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTranssphenoidal surgery (TSS) is the primary treatment modality for Cushing's disease (CD). However, the predictors of post-operative remission and recurrence remain debatable. Thus, we studied the post-operative remission and long-term recurrence rates, as well as their respective predictive factors.
methodsA retrospective analysis of case records of 230 CD patients who underwent primary microscopic TSS at our tertiary care referral centre between 1987 and 2015 was undertaken. Demographic features, pre- and post-operative hormonal values, MRI findings, histopathological features and follow-up data were recorded. Remission and recurrence rates as well as their respective predictive factors were studied.
resultsOverall, the post-operative remission rate was 65.6% (early remission 46%; delayed remission 19.6%), while the recurrence rate was 41% at mean follow-up of 74 ± 61.1 months (12-270 months). Significantly higher early remission rates were observed in patients with microadenoma vs macroadenoma (51.7% vs 30.6%,
conclusionIn our study, remission and recurrence rates were similar to that of reported literature, but proportion of delayed remission was relatively higher. Negative/equivocal MRI findings and presence of macroadenoma, especially those with cavernous sinus invasion were predictors of poor remission rates. In addition to early remission, longer duration of post-operative hypocortisolism is an important predictor of sustained remission. Regular biochemical surveillance may help in identifying recurrence early.
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