Evidence map›Paper›PMID 28912302›Full record

ArticleJournal of lipid research2017

Prevention of renal apoB retention is protective against diabetic nephropathy: role of TGF-β inhibition.

Patricia G Wilson, Joel C Thompson, Meghan H Yoder, Richard Charnigo, Lisa R Tannock

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. [Bioinformatics Analysis of Hub Genes of Diabetic Foot Ulcer and Their Biofunctions].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Patricia G WilsonDepartment of Veterans Affairs, Lexington, KY 40502.
Joel C ThompsonDepartment of Veterans Affairs, Lexington, KY 40502.
Meghan H YoderDepartment of Veterans Affairs, Lexington, KY 40502.
Richard CharnigoDepartment of Statistics, University of Kentucky, Lexington, KY 40536.
Lisa R TannockDepartment of Veterans Affairs, Lexington, KY 40502 lisa.tannock@uky.edu.
University of Kentucky · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Mechanisms of Renal Lipid Accumulation in Diabetic NephropathyI01BX000622 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI TANNOCK, LISA R · 2009 to 2013
–
BLRD VA I01 BX000622NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

Animal studies demonstrate that hyperlipidemia and renal lipid accumulation contribute to the pathogenesis of diabetic nephropathy (DN). We previously demonstrated that renal lipoproteins colocalize with biglycan, a renal proteoglycan. The purpose of this study was to determine whether prevention of renal lipid (apoB) accumulation attenuates DN. Biglycan-deficient and biglycan wild-type

Indexed as

AlbuminuriaAnimalsAntibodies, NeutralizingApolipoprotein B-100Apolipoproteins BBiglycanDiabetes Mellitus, ExperimentalDiabetic NephropathiesDiet, High-FatKidneyMaleMiceMice, Inbred C57BLMice, KnockoutReceptors, LDLStreptozocinAntibodies, NeutralizingApob protein, mouseApolipoprotein B-100Apolipoproteins BBiglycanReceptors, LDLStreptozocinTransforming Growth Factor betaapolipoprotein Bbiglycancholesteroldiabetesextracellular matrixkidneyproteoglycanstransforming growth factor-β

Identifiers

PMID28912302
PMCPMC5711490
OpenAlexW2756225903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.