Evidence map›Paper›PMID 28912269›Full record

ArticleThe Journal of biological chemistry2017

Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis.

Bill X Wu, Anqi Li, Liming Lei, Satoshi Kaneko, Caroline Wallace, Xue Li, Zihai Li

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. A specialized integrin-binding motif enables proTGF-β2 activation by integrin αVβ6 but not αVβ8.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
  5. Article
  6. A Novel Homozygous Missense Variant in theFrontiers in pediatrics · 2022
    Article
  7. Review
  8. Article
  9. Inducers, Attractors and Modulators of CD4Frontiers in immunology · 2020
    Review
  10. Review
  11. Truncation of TGF-β docking receptor GARP is linked to human disease.European journal of human genetics : EJHG · 2019
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Bill X WuFrom the Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425.
Anqi LiFrom the Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425.
Liming Leithe Departments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and.
Satoshi Kanekothe Departments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and.
Caroline WallaceFrom the Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425.
Xue Lithe Departments of Urology and Surgery, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, and.
Zihai LiFrom the Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, zihai@musc.edu.
MUSC Hollings Cancer Center · USBoston Children's Hospital · USHarvard University · USMedical University of South Carolina · US

Funding

Project 3: Structural Basis for grp94 Drug Development and Chaperone FunctionP01CA186866 · NCI · OHIO STATE UNIVERSITY · PI LI, ZIHAI · 2015 to 2019
$6.7M
Roles and Mechanisms of gp96 in Chaperoning Innate ImmunityR01AI070603 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LI, ZIHAI · 2007 to 2016
$3.8M
The Six-Family Genes in Cardiovascular Development And DiseaseR01HL136921 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2020
$2.3M
Molecular Basis of Sexually Dimorphic Development of the Genital TubercleR01DK110477 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI LI, XUE SEAN · 2017 to 2021
$1.9M
NCI NIH HHS P01 CA186866NHLBI NIH HHS R01 HL136921NIAID NIH HHS R01 AI070603NIDDK NIH HHS R01 DK110477
6 · The paper itself

Abstract

Glycoprotein A repetitions predominant (GARP) (encoded by the

Indexed as

Gene Expression Regulation, DevelopmentalOrganogenesisProtein Processing, Post-TranslationalAnimalsAnimals, NewbornApoptosisCleft PalateEmbryo, MammalianFemaleGene Knock-In TechniquesHEK293 CellsHeterozygoteHumansMembrane ProteinsMice, KnockoutPalateLrrc32 protein, mouseMembrane ProteinsRecombinant Fusion ProteinsSmad2 ProteinSmad2 protein, mouseTgfb3 protein, mouseTransforming Growth Factor beta3apoptosiscell signalingdevelopmentembryoGARP, palatogenesisTGFβ

Identifiers

PMID28912269
PMCPMC5672034
OpenAlexW2756109197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.