Evidence map›Paper›PMID 28912194›Full record

ArticleBMJ open2017

Assessing oral medication adherence among patients with type 2 diabetes mellitus treated with polytherapy in a developed Asian community: a cross-sectional study.

Cia Sin Lee, Jane Hwee Mian Tan, Usha Sankari, Yi Ling Eileen Koh, Ngiap Chuan Tan

Registry-linked trialAbstract read
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In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06837428 (Peer Comparison-based Risk Communication), which is not on this map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06837428 nacompletednot on this mapstarted 2023, after this paper: background citation

Peer Comparison-based Risk Communication (PRICOM): A Study Protocol to Evaluate the Feasibility of Delivering a Risk Communication Intervention in the Primary Care Setting for Adults With Type 2 Diabetes Mellitus

TypeinterventionalSponsorSingHealth PolyclinicsRan2023 to 2024Enrolled40ConditionsDiabetes Type 2ArmsPeer comparison-based Risk Communication (PRICOM)
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Medication adherence in adults after hospitalization for heart failure: A cross-sectional study.International journal of cardiology. Cardiovascular risk and prevention · 2024
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  16. Mesenteric fat cryolipolysis attenuates insulin resistance in the Ossabaw swine model of the metabolic syndrome.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cia Sin LeeSingHealth Polyclinics, Singapore, Singapore.
Jane Hwee Mian TanSingHealth Polyclinics, Singapore, Singapore.
Usha SankariSingHealth Polyclinics, Singapore, Singapore.
Yi Ling Eileen KohSingHealth Polyclinics, Singapore, Singapore.
Ngiap Chuan TanSingHealth Polyclinics, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe disease burden of type 2 diabetes mellitus (T2DM) is rising due to suboptimal glycaemic control leading to vascular complications. Medication adherence (MA) directly influences glycaemic control and clinical consequences. This study aimed to assess the MA of patients with T2DM and identify associated factors.

designAnalysis of data from a cross-sectional survey and electronic medical records.

settingPrimary care outpatient clinic in Singapore.

participantsAdult patients with T2DM.

main outcome measuresMA to each prescribed oral hypoglycaemic agent (OHA) was measured using the five-question Medication Adherence Report Scale (MARS-5). Low MA is defined as a MARS-R score of <25. Demographic data, clinical characteristics and investigation results were collected to identify factors that are associated with low MA.

resultsThe study population comprised 382 patients with a slight female predominance (53.4%) and a mean±SD age of 62.0±10.4 years. 57.1% of the patients had low MA to at least one OHA. Univariate analysis showed that patients who were younger, of Chinese ethnicity, married or widowed, self-administering their medications or taking fewer (four or less) daily medications tended to have low MA to OHA. Logistic regression revealed that younger age (OR 0.97; 95% CI 0.95 to0.99), Chinese ethnicity (OR 2.80; 95% CI 1.53 to5.15) and poorer glycaemic control (HbA1c level) (OR 1.27; 95% CI 1.06 to1.51) were associated with low MA to OHA.

conclusionsYounger patients with T2DM and of Chinese ethnicity were susceptible to low MA to OHA, which was associated with poorer glycaemic control. Polytherapy was not associated with low MA.

Indexed as

Asian PeopleEthnicityMedication AdherenceAgedAge FactorsBlood GlucoseCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansHypoglycemic AgentsLogistic ModelsMaleMiddle AgedOdds RatioBlood GlucoseGlycated HemoglobinHypoglycemic Agentsmedication adherenceoral hypoglycemic agentpolytherapytype 2 diabetes mellitus

Identifiers

PMID28912194
PMCPMC5640112

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.