Evidence map›Paper›PMID 28912168›Full record

ArticleMolecular cancer research : MCR2017

Alternative Polyadenylation of

Austin E Gillen, Heather M Brechbuhl, Tomomi M Yamamoto, Enos Kline, Manoj M Pillai, Jay R Hesselberth, Peter Kabos

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Reduced Usage ofPhenomics (Cham, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. The Detection and Bioinformatic Analysis of Alternative 3International journal of molecular sciences · 2021
    Review
  13. Article
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Austin E GillenUniversity of Colorado School of Medicine, RNA Bioscience Initiative, Aurora, Colorado. peter.kabos@ucdenver.edu austin.gillen@ucdenver.edu.
Heather M BrechbuhlUniversity of Colorado School of Medicine, Department of Medicine, Aurora, Colorado.
Tomomi M YamamotoUniversity of Colorado School of Medicine, Department of Medicine, Aurora, Colorado.
Enos KlineUniversity of Colorado School of Medicine, Department of Medicine, Aurora, Colorado.
Manoj M PillaiYale Cancer Center, Section of Hematology, New Haven, Connecticut.
Jay R HesselberthUniversity of Colorado School of Medicine, RNA Bioscience Initiative, Aurora, Colorado.
Peter KabosUniversity of Colorado School of Medicine, RNA Bioscience Initiative, Aurora, Colorado. peter.kabos@ucdenver.edu austin.gillen@ucdenver.edu.
University of Colorado Denver · USYale Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Cancer-associated fibroblasts in estrogen receptor positive breast cancer.R01CA205044 · NCI · UNIVERSITY OF COLORADO DENVER · PI KABOS, PETER · 2016 to 2020
$1.8M
Deregulation of SF3B1 function by recurrent HEAT domain mutationsR01HL133406 · NHLBI · YALE UNIVERSITY · PI NEUGEBAUER, KARLA M, PILLAI, MANOJ M. · 2017 to 2020
$1.7M
Regulation of anti-endocrine resistance of breast cancer by a network of non-codiK08CA164048 · NCI · UNIVERSITY OF COLORADO DENVER · PI KABOS, PETER · 2012 to 2016
$859k
NCI NIH HHS K08 CA164048NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA205044NHLBI NIH HHS R01 HL133406
6 · The paper itself

Abstract

Disruption of posttranscriptional gene regulation is a critical step in oncogenesis that can be difficult to observe using traditional molecular techniques. To overcome this limitation, a modified polyadenylation site sequencing (PAS-seq) protocol was used to generate a genome-wide map of alternative polyadenylation (APA) events in human primary breast tumor specimens and matched normal tissue. This approach identified an APA event in the

Indexed as

3' Untranslated RegionsBreast NeoplasmsCarcinogenesisDisease-Free SurvivalFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsMitochondriaMitochondrial ProteinsPolyadenylationReactive Oxygen Species3' Untranslated RegionsMitochondrial ProteinsPRELID1 protein, humanReactive Oxygen Species

Identifiers

PMID28912168
PMCPMC5791535
OpenAlexW2754362077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.