Evidence map›Paper›PMID 28912123›Full record

ArticleEMBO reports2017

Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities.

Ann Ray, Nika Schwartz, Marcela de Souza Santos, Junmei Zhang, Kim Orth, Dor Salomon

Open access · hybridAbstract read
In one paragraph

Article in EMBO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The SPI-6 T6SS gene cluster fromFrontiers in microbiology · 2026
    Article
  6. The SPI-20 and SPI-21 T6SS gene clusters fromFrontiers in microbiology · 2026
    Article
  7. Article
  8. Deciphering theJournal of bacteriology · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. AMicrobiology spectrum · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ann RayDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Nika SchwartzDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Marcela de Souza SantosDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Junmei ZhangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kim OrthDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-0678-7620
Dor SalomonDepartment of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel dorsalomon@mail.tau.ac.il.ORCID 0000-0002-2009-9453
Howard Hughes Medical Institute · USTel Aviv University · ILThe University of Texas Southwestern Medical Center · US

Funding

UT GASTROENTEROLOGY/HEPATOLOGY RESEARCH TRAINING PROGRAMT32DK007745 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Rodney E Infante · 1997 to 2026
$6.8M
Analysis of an orchestrated cell death mediated by Vibrio parahaemolytics T3SS1R01AI087808 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ORTH, KIM · 2010 to 2014
$1.9M
European Research Council 714224NIAID NIH HHS R01 AI087808NIDDK NIH HHS T32 DK007745
6 · The paper itself

Abstract

Most type VI secretion systems (T6SSs) described to date are protein delivery apparatuses that mediate bactericidal activities. Several T6SSs were also reported to mediate virulence activities, although only few anti-eukaryotic effectors have been described. Here, we identify three T6SSs in the marine bacterium

Indexed as

Gene Expression Regulation, BacterialActin CytoskeletonAnimalsAnti-Bacterial AgentsAquatic OrganismsBacterial ProteinsBacterial ToxinsChromosome MappingChromosomes, BacterialCoculture TechniquesEscherichia coliEscherichia coli ProteinsMicePhagocytesProtein DomainsRAW 264.7 CellsAnti-Bacterial AgentsBacterial ProteinsBacterial Toxinscytotoxic necrotizing factor type 1Escherichia coli ProteinsType VI Secretion Systemsbacterial competitionCNF1Vibriovirulence

Identifiers

PMID28912123
PMCPMC5666596
OpenAlexW2755704972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.