ArticleCirculation research2017
Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction.
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Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Changes in myocardial elasticity derived from in-vivo cardiac MRI in a swine model of ischemic heart failure.Scientific reports · 2026Article
- Post-myocardial Infarction Cardiac Remodeling: Multidimensional Mechanisms and Clinical Prospects of Stem Cell Therapy.Stem cell reviews and reports · 2025Review
- Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts.Communications biology · 2023Article
- Bone Marrow and Wharton's Jelly Mesenchymal Stromal Cells are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy.Stem cell reviews and reports · 2023Article
- Advances in pig models of human diseases.Animal models and experimental medicine · 2022Review
- Porcine Models of Heart Regeneration.Journal of cardiovascular development and disease · 2022Review
- Systemic delivery of large-scale manufactured Wharton's Jelly mesenchymal stem cell-derived extracellular vesicles improves cardiac function after myocardial infarction.The journal of cardiovascular aging · 2022Article
- Cortical bone stem cell-derived exosomes' therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype.American journal of physiology. Heart and circulatory physiology · 2021Article
- Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation.International journal of molecular sciences · 2021Article
- Neovascularization: The Main Mechanism of MSCs in Ischemic Heart Disease Therapy.Frontiers in cardiovascular medicine · 2021Review
- Current Status and Limitations of Myocardial Infarction Large Animal Models in Cardiovascular Translational Research.Frontiers in bioengineering and biotechnology · 2021Review
- Article
- Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice.Scientific reports · 2020Article
- A realistic appraisal of the use of embryonic stem cell-based therapies for cardiac repair.European heart journal · 2020Article
- An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs.Science translational medicine · 2020Article
- Healing the Broken Heart; The Immunomodulatory Effects of Stem Cell Therapy.Frontiers in immunology · 2020Review
- Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury.Frontiers in cell and developmental biology · 2020Article
- Scar Formation with Decreased Cardiac Function Following Ischemia/Reperfusion Injury in 1 Month Old Swine.Journal of cardiovascular development and disease · 2019Article
- Ubiquitin‑proteasomes are the dominant mediators of the regulatory effect of microRNA‑1 on cardiac remodeling after myocardial infarction.International journal of molecular medicine · 2019Article
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Authors and funding
18 authors at 2 institutions in 1 country.
Thomas E SharpFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Giana J SchenaFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Alexander R HobbyFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Timothy StarostaFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Remus M BerrettaFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Markus WallnerFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Giulia BorghettiFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Polina GrossFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Daohai YuFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Jaslyn JohnsonFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Eric FeldsottFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Danielle M TrappaneseFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Amir ToibFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Joseph E RabinowitzFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Jon C GeorgeFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Hajime KuboFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Sadia MohsinFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.).
Steven R HouserFrom the Department of Physiology, Cardiovascular Research Center (T.E.S., G.J.S., A.R.H., T.S., R.M.B., M.W., G.B., P.G., J.J., E.F., D.M.T., A.T., J.C.G., H.K., S.M., S.R.H.), Department of Clinical Sciences, Temple Clinical Research Institute (D.Y.), and Department of Pharmacology, Center for Translational Medicine (J.E.R.), Temple University Lewis Katz School of Medicine, Philadelphia, PA; Department of Cardiology, Temple University Hospital, Philadelphia, PA (J.C.G.); Section of Pediatric Cardiology, St. Christopher's Hospital for Children, Philadelphia, PA (A.T.); and Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD (T.S.). srhouser@temple.edu.
St. Christopher's Hospital for Children · USTemple University Hospital · US
Funding
PKC alpha as a translational target in Heart FailureP01HL108806 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RABINOWITZ, JOSEPH E · 2012 to 2016
$11.3MCalcium and Cardiac Regeneration after Myocardial InfarctionR01HL033921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 1985 to 2017
$5.6MCortical Bone Stem Cell Therapy for the Infarcted HeartR01HL139960 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2018 to 2021
$2.5MParacrine Modulation of Cardiac Repairprocesses by Cortical Bone Derived Stem CellsR56HL137850 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MOHSIN, SADIA · 2017 to 2017
$396kNHLBI NIH HHS P01 HL108806NHLBI NIH HHS R01 HL033921NHLBI NIH HHS R01 HL139960NHLBI NIH HHS R56 HL137850
Abstract
rationaleCortical bone stem cells (CBSCs) have been shown to reduce ventricular remodeling and improve cardiac function in a murine myocardial infarction (MI) model. These effects were superior to other stem cell types that have been used in recent early-stage clinical trials. However, CBSC efficacy has not been tested in a preclinical large animal model using approaches that could be applied to patients.
objectiveTo determine whether post-MI transendocardial injection of allogeneic CBSCs reduces pathological structural and functional remodeling and prevents the development of heart failure in a swine MI model. METHODS AND
resultsFemale Göttingen swine underwent left anterior descending coronary artery occlusion, followed by reperfusion (ischemia-reperfusion MI). Animals received, in a randomized, blinded manner, 1:1 ratio, CBSCs (n=9; 2×10
conclusionsCBSC administration into the MI border zone reduces pathological cardiac structural and functional remodeling and improves left ventricular functional reserve. These effects reduce those processes that can lead to heart failure with reduced ejection fraction.
Indexed as
Ventricular Function, LeftVentricular RemodelingAnimalsApoptosisArrhythmias, CardiacCell ProliferationCells, CulturedCortical BoneDisease Models, AnimalFemaleHemodynamicsMyocardial ContractionMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumPhenotypecell therapyhemodynamicsmyocardial infarctionstem cellsswineventricular remodeling
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