Evidence map›Paper›PMID 28911764›Full record

ArticleThe Lancet. Global health2017

Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series.

Nienke M Scheltema, Angela Gentile, Florencia Lucion, D James Nokes, Patrick K Munywoki, Shabir A Madhi, Michelle J Groome, Cheryl Cohen, Jocelyn Moyes, Kentigern Thorburn and 38 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Global health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 135 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 12 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 12 syntheses or guidelines pooled it, 245 citations in OpenAlex.

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75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

48 authors at 20 institutions in 23 countries.

Nienke M ScheltemaDepartment of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, Netherlands.
Angela GentileDepartment of Epidemiology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
Florencia LucionDepartment of Epidemiology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
D James NokesKenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya; School of Life Sciences, University of Warwick, Coventry, UK.
Patrick K MunywokiKenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya; Department of Nursing Sciences, Pwani University, Kilifi, Kenya.
Shabir A MadhiMedical Research Council: Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa.
Michelle J GroomeMedical Research Council: Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa.
Cheryl CohenSchool of Public Health, University of the Witwatersrand, Johannesburg, South Africa; Centre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
Jocelyn MoyesCentre for Respiratory Disease and Meningitis, National Institute for Communicable Diseases, Johannesburg, South Africa.
Kentigern ThorburnDepartment of Paediatric Intensive Care, Alder Hey Children's Hospital, Liverpool, UK.
Somsak ThamthitiwatDivision of Global Health Protection, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.
Hitoshi OshitaniDepartment of Virology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Miyagi, Japan.
Socorro P LupisanResearch Institute for Tropical Medicine, Alabang Muntinlupa City, Metro Manila Philippines.
Aubree GordonDepartment of Epidemiology, School of Public Health, University of Michigan, MI, USA.
José F SánchezDepartment of Medicine, Hospital Infantil Manuel de Jesus Rivera, Managua, Nicaragua.
Katherine L O'BrienInternational Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
PERCH Study Group
Bradford D GessnerAgence de Medecine Preventive, Paris, France.
Agustinus SutantoWest Nusa Tenggara Provincial Government, Lombok, Indonesia.
Asuncion MejiasDepartment of Pediatrics, Division of Infectious Diseases, Ohio State University, Columbus, OH, USA; Center for Vaccines and Immunity at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.
Octavio RamiloDepartment of Pediatrics, Division of Infectious Diseases, Ohio State University, Columbus, OH, USA; Center for Vaccines and Immunity at Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA.
Najwa Khuri-BulosDepartment of Pediatrics, University of Jordan, Aljubeiha, Amman, Jordan.
Natasha HalasaVanderbilt University Medical Center, Nashville, TN, USA.
Fernanda de-ParisMolecular Biology Laboratory, Hospital de Clínicas de Porto Alegre, Bairro Santa Cecília, Porto Alegre, Brazil.
Márcia Rosane PiresInfection Control Commission, Hospital de Clínicas de Porto Alegre, Bairro Santa Cecília, Porto Alegre, Brazil.
Michael C SpaederDivision of Pediatric Critical Care, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bosco A PaesNeonatal Division, Department of Pediatrics, McMaster University, Hamilton, ON, Canada.
Eric A F SimõesDepartment of Pediatrics and Center for Global Health, University of Colorado, Aurora, CO, USA.
Ting F LeungDepartment of Paediatrics, Faculty of Medicine and Chinese University of Hong Kong-University Medical Center Utrecht Joint Research Laboratory of Respiratory Virus and Immunobiology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China.
Maria Tereza da Costa OliveiraHealth Secretariat of the City of Belo Horizonte, Belo Horizonte, Brazil.
Carla Cecília de Freitas Lázaro EmediatoHealth Secretariat of the City of Belo Horizonte, Belo Horizonte, Brazil.
Quique BassatISGlobal, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain; Department of Pediatrics, Hospital Sant Joan de Déu, Barcelona, Spain; Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique; Faculty of Medicine, Universidad Europea de Madrid, Madrid, Spain.
Warwick ButtDepartment of Intensive Care, Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Murdoch Children's Research Institute, Parkville, VIC, Australia.
Hsin ChiDepartment of Pediatric Infectious Disease, MacKay Children's Hospital, Taipei, Taiwan.
Uzma Bashir AamirDepartment of Virology, National Institute of Health, Islamabad, Pakistan.
Asad AliDepartment of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Marilla G LuceroResearch Institute for Tropical Medicine, Alabang Muntinlupa City, Metro Manila Philippines.
Rodrigo A FascePublic Health Institute, Ñuñoa, Santiago, Chile.
Olga LopezHospital Dr. Ernesto Torres Galdames, Iquique, Chile.
Barbara A RathVienna Vaccine Safety Initiative, Berlin, Germany; University of Nottingham School of Medicine, Nottingham, UK.
Fernando P PolackFundacion Infant, Buenos Aires, Argentina.
Jesse PapenburgDepartment of Microbiology, Division of Pediatric Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada.
Srđan RoglićDepartment of Paediatric Infectious Diseases, University Hospital for Infectious Diseases, Zagreb, Croatia.
Hisato ItoDepartment of Pediatrics, Nantan General Hospital, Ueno, Yagichoyagi, Nantan-shi, Kyoto, Japan.
Edward A GokaSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Diederick E GrobbeeJulius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Julius Clinical Science, Zeist, Netherlands.
Harish NairCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Louis J BontDepartment of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, Netherlands; ReSViNET Respiratory Syncytial Virus Network, Utrecht, Netherlands. Electronic address: l.bont@umcutrecht.nl.
Hospital de Clínicas de Porto Alegre · BRHospital General de Niños Ricardo Gutierrez · ARKenya Medical Research Institute · KENational Research Foundation · ZAPrefeitura Municipal de Belo Horizonte · BRResearch Institute for Tropical Medicine · PHWilhelmina Children's Hospital · NLAga Khan University · PKAgence de Médecine Préventive · FRCenter for Global Health · USChinese University of Hong Kong · CNHospital Infantil Manuel de Jesús Rivera · NIInfant Foundation · ARInstituto de Salud Pública de Chile · CLJohns Hopkins University · USMackay Memorial Hospital · TWMcGill University Health Centre · CAMcMaster University · CAMinistry of Public Health · THNantan General Hospital · JP

Funding

Research on the Epidemiology,Prevention,Vaccine Effectiveness and Treatment of Influenza and Other Respiratory Viruses in South Africa.09U01IP001048 · IP · NATIONAL HEALTH LABORATORY SERVICE · PI COHEN, CHERYL · 2016 to 2020
$19.9M
NCIRD CDC HHS U01 IP001048Wellcome Trust
6 · The paper itself

Abstract

backgroundRespiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data.

methodsIn this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. For the literature search, we searched PubMed for articles published up to Feb 3, 2015, using the key terms "RSV", "respiratory syncytial virus", or "respiratory syncytial viral" combined with "mortality", "fatality", "death", "died", "deaths", or "CFR" for articles published in English. We invited researchers and clinicians identified to participate between Nov 1, 2014, and Oct 31, 2015. We calculated descriptive statistics for all variables.

findingsWe studied 358 children with RSV-related in-hospital death from 23 countries across the world, with data contributed from 31 research groups. 117 (33%) children were from low-income or lower middle-income countries, 77 (22%) were from upper middle-income countries, and 164 (46%) were from high-income countries. 190 (53%) were male. Data for comorbidities were missing for some children in low-income and middle-income countries. Available data showed that comorbidities were present in at least 33 (28%) children from low-income or lower middle-income countries, 36 (47%) from upper middle-income countries, and 114 (70%) from high-income countries. Median age for RSV-related deaths was 5·0 months (IQR 2·3-11·0) in low-income or lower middle-income countries, 4·0 years (2·0-10·0) in upper middle-income countries, and 7·0 years (3·6-16·8) in high-income countries.

interpretationThis study is the first large case series of children who died with community-acquired RSV infection. A substantial proportion of children with RSV-related death had comorbidities. Our results show that perinatal immunisation strategies for children aged younger than 6 months could have a substantial impact on RSV-related child mortality in low-income and middle-income countries.

fundingBill & Melinda Gates Foundation.

Indexed as

Child, PreschoolFemaleGlobal HealthHumansInfantInfant, NewbornMaleRespiratory Syncytial Virus InfectionsRetrospective Studies

Identifiers

PMID28911764
PMCPMC5599304
OpenAlexW2755200049

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.