ArticleJournal of food and drug analysis2017
Microbiological, histological, and biochemical evidence for the adverse effects of food azo dyes on rats.
Article in Journal of food and drug analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Potential impacts of synthetic food dyes on activity and attention in children: a review of the human and animal evidence.Environmental health : a global access science source · 2022Pooled it
- Comparative developmental toxicity and oxidative stress of synthetic and natural yellow food colorants in zebrafish (Toxicology reports · 2026Article
- Ameliorative potential of pomegranate juice against synthetic colorant (E124)-induced biochemical and histopathological changes in the rat brain and testes.Food chemistry. Molecular sciences · 2026Article
- Novel dihydroxybenzohydrazide grafted deoxycellulose for efficient removal of anionic food colorants and hexavalent chromium from wastewater.Scientific reports · 2025Article
- Article
- Potential of halophiles and alkaliphiles in bioremediation of azo dyes-laden textile wastewater: a review.3 Biotech · 2024Review
- Review
- Comparison of the effect of Sunset yellow on the stomach and small intestine of developmental period of mice.Heliyon · 2024Article
- Determination of the effects of sunset yellow on mouse liver and pancreas using histological methods.Toxicology research · 2024Article
- Determination of the Effects of Ankaferd Wound Dressing on the Wound Healing Process in Rats.Turkish journal of pharmaceutical sciences · 2024Article
- Carbon-paste electrode modified by β-cyclodextrin as sensor for voltammetric determination of Tartrazine and Carmoisine from one drop.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022Article
- Effects of the food colorant carmoisine on zebrafish embryos at a wide range of concentrations.Archives of toxicology · 2022Article
- Three-way analysis-based pH-UV-Vis spectroscopy for quantifying allura red in an energy drink and determining colorant's pKa.Journal of food and drug analysis · 2021Article
- The Embryotoxic Effects of in Ovo Administered Sunset Yellow FCF in Chick Embryos.Veterinary sciences · 2021Article
- Effects of Sunset Yellow FCF on Immune System Organs During Different Chicken Embryonic Periods.Journal of veterinary research · 2020Article
- Evaluation of contact sensitivity to food additives in children with atopic dermatitis.Postepy dermatologii i alergologii · 2020Article
- Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- Azoreductase activity of dye-decolorizing bacteria isolated from the human gut microbiota.Scientific reports · 2019Article
- Histological and immunohistochemical evaluation of the effect of tartrazine on the cerebellum, submandibular glands, and kidneys of adult male albino rats.Environmental science and pollution research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, 120 lactic acid bacterial strains from different fermented dairy products as well as 10 bacterial intestinal isolates were evaluated for in vitro and in vivo degradation of various food azo dyes. Of these isolates, lactic acid bacteria (LAB) strains 13 and 100 and the intestinal isolates Ent2 and Eco5 exhibited 96-98% degradation of the tested food azo dyes within 5-6 hours. High performance liquid chromatography mass spectra of sunset yellow (E110) and carmoisine (E122) anaerobic degradation products by the intestinal isolates showed that they were structurally related to toxic aromatic amines. For an in vivo study, eight groups of rats were treated for 90 days with either the food azo dyes or their degradation products. All groups were kept for a further 30 days as recovery period and then dissected at 120 days. Hematological, histopathological, and protein markers were assessed. Rats treated with either E110/E122 or their degradation products exhibited highly significant changes in red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and white blood cell count. In addition, alanine and aspartate aminotransferases, amylase, total bilirubin, blood urea nitrogen, creatinine, glucose, total protein, and globulins were significantly increased. Furthermore, marked histopathological alterations in the liver, kidney, spleen, and small intestine were observed. Significant decreases in inflammation and a noticeable improvement in the liver, kidney, spleen, and small intestine of rats treated with LAB and food azo dyes simultaneously were observed. Finally, these results provide a reliable basis for not only a better understanding of the histological and biochemical effects of food additives, but also for early diagnostics. In addition, LAB strains 13 and 100 may play an important role as potential probiotics in food and dairy technology as a probiotic lactic acid starter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.