Evidence map›Paper›PMID 28911642›Full record

ArticleJournal of food and drug analysis2017

Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice.

Yi-Hsing Chen, Chieh-Shan Wu, Ya-Husan Chao, Chi-Chen Lin, Hui-Yun Tsai, Yi-Rong Li, Yi-Zhen Chen, Wan-Hua Tsai, Yu-Kuo Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food and drug analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Anti-Psoriatic activity ofOpen veterinary journal · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Gut-skin axis: Emerging insights for gastroenterologists-a narrative review.World journal of gastrointestinal pathophysiology · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Cholesterol-Lowering Activity ofJournal of microbiology and biotechnology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi-Hsing ChenInstitute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
Chieh-Shan WuInstitute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
Ya-Husan ChaoInstitute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
Chi-Chen LinInstitute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
Hui-Yun TsaiDepartment of Food Science, Rutgers University, New Brunswick, NJ, USA.
Yi-Rong LiInstitute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung-Hsing University, Taichung, Taiwan.
Yi-Zhen ChenDepartment of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan.
Wan-Hua TsaiResearch and Development Department, GenMont Biotech Incorporation, Tainan, Taiwan.
Yu-Kuo ChenDepartment of Food Science, National Pingtung University of Science and Technology, Pingtung, Taiwan.
National Chung Hsing University · TWRutgers, The State University of New Jersey · USGenMont Biotech (Taiwan) · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis, which is regarded as a T-cell-mediated chronic inflammatory skin disease, is characterized by hyperproliferation and poor differentiation of epidermal keratinocytes. In this study, we aimed to determine the in vivo effect of a potentially probiotic strain, Lactobacillus pentosus GMNL-77, in imiquimod-induced epidermal hyperplasia and psoriasis-like skin inflammation in BALB/c mice. Oral administration of L. pentosus GMNL-77 significantly decreased erythematous scaling lesions. Real-time polymerase chain reaction showed that treatment with L. pentosus GMNL-77 significantly decreased the mRNA levels of proinflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-6, and the IL-23/IL-17A axis-associated cytokines (IL-23, IL-17A/F, and IL-22) in the skin of imiquimod-treated mice. In addition, we found that L. pentosus GMNL-77 decreased the spleen weights of the imiquimod-treated group and reduced the numbers of IL-17- and IL-22-producing CD4

Indexed as

Lactiplantibacillus pentosusAminoquinolinesAnimalsImiquimodInterleukin-17MicePsoriasisAminoquinolinesImiquimodInterleukin-17cytokinesimiquimodinflammationLactobacillus pentosus GMNL-77psoriasisT cells

Identifiers

PMID28911642
PMCPMC9328808
OpenAlexW2500393173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.