ArticleJournal of food and drug analysis2016
Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice.
Article in Journal of food and drug analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Efficacy and safety of TCM Yangxin Anshen Therapy for insomnia: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved.Foods (Basel, Switzerland) · 2025Review
- Lignans-rich extract ofCurrent research in food science · 2025Article
- Research progress on the effect of medicine and food homology resources for sleep improvement.Heliyon · 2024Review
- Tissue-specific transcriptome and metabolome analyses reveal candidate genes for lignan biosynthesis in the medicinal plant Schisandra sphenanthera.BMC genomics · 2023Article
- Simultaneous Extraction and Determination of Lignans fromMolecules (Basel, Switzerland) · 2023Article
- Schisandra extract ameliorates arthritis pathogenesis by suppressing the NF-κB and MAPK signalling pathways.Journal of cellular and molecular medicine · 2023Article
- Screening of Q-markers for the wine-steamed Schisandra chinensis decoction pieces in improving allergic asthma.Chinese medicine · 2023Article
- Schisandrin B exerts hypnotic effects in PCPA-treated rats by increasing hypothalamic 5-HT and γ-aminobutyric acid levels.Experimental and therapeutic medicine · 2020Article
- Associations of Urinary Phytoestrogen Concentrations with Sleep Disorders and Sleep Duration among Adults.Nutrients · 2020Article
- Hypnotic Effects ofNutrients · 2019Article
- Neuroprotective Effect of Schisandra Chinensis on Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinsonian Syndrome in C57BL/6 Mice.Nutrients · 2019Article
- Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems.Nutrition research and practice · 2018Article
- Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC-MS/MS Method.Molecules (Basel, Switzerland) · 2018Article
- The Cytochrome P450-Mediated Metabolism Alternation of Four Effective Lignans FromFrontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schisandra chinensis is a traditional Chinese medicine that has been used for treating insomnia and neurasthenia for centuries. Lignans, which are considered to be the bioactive components, are apt to be extracted by supercritical carbon dioxide. This study was conducted to investigate the sedative and hypnotic activities of the supercritical carbon dioxide fluid extraction of S. chinensis (SFES) in mice and the possible mechanisms. SFES exhibited an obvious sedative effect on shortening the locomotor activity in mice in a dose-dependent (10-200 mg/kg) manner. SFES (50 mg/kg, 100 mg/kg, and 200 mg/kg, intragstrically) showed a strong hypnotic effect in synergy with pentobarbital in mouse sleep, and reversal of insomnia induced by caffeine, p-chlorophenylalanine and flumazenil by decreasing sleep latency, sleep recovery, and increasing sleeping time. In addition, it produced a synergistic effect with 5-hydroxytryptophan (2.5 mg/kg, intraperitoneally). The behavioral pharmacological results suggest that SFES has significant sedative and hypnotic activities, and the mechanisms might be relevant to the serotonergic and γ-aminobutyric acid (GABA)ergic system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.