ReviewJournal of food and drug analysis2017
Chemistry and health effects of furanocoumarins in grapefruit.
Review in Journal of food and drug analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 178 citations in OpenAlex.
- Severe rise in tacrolimus levels following blood orange and grapefruit juice intake in a kidney transplant recipient: a case report.Journal of medical case reports · 2026Article
- Bergapten as a Multifunctional Phytochemical in Cancer Therapy: Mechanistic Insights, Pharmacokinetics, and Possible Nanotechnology-Enabled Formulation Strategies.Pharmaceutics · 2026Review
- Life cycle, seasonal- and tissue-dependent metabolite composition, and high (E)-Ligustilide content characterize the ethnobotany of a Native American medicinal plant, Lomatium foeniculaceum.Journal of natural medicines · 2026Article
- Exploratory Genome-Wide Association Study of Grapefruit Intake and Its Potential Link to Obesity Risk in US Cohorts.Nutrients · 2026Article
- Comprehensive analysis of3 Biotech · 2025Article
- Fast Determination of Furocoumarins in Food Supplements ContainingFoods (Basel, Switzerland) · 2025Article
- Flavonoids and Furanocoumarins Involved in Drug Interactions.Molecules (Basel, Switzerland) · 2025Review
- The metabolic ability of swallowtails results in the production of bioactive substances from plant components.PloS one · 2025Article
- The Role of Stem Cell Polyphenols in Wound Healing: A Narrative Review.World journal of plastic surgery · 2025Review
- Structural Insights and Biological Activities of Furan-Based Drugs in the Treatment of Human Diseases.Combinatorial chemistry & high throughput screening · 2025Review
- The underappreciated diversity of furanocoumarins in grapefruits revealed by MassQL filtered molecular networking.Food chemistry: X · 2025Article
- A review of the ethnomedicinal, phytochemical, and pharmacological properties of the Ferulago genus based on Structure-Activity Relationship (SAR) of coumarins.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Article
- Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity.Molecules (Basel, Switzerland) · 2024Review
- Furanocoumarins as Enhancers of Antitumor Potential of Sorafenib and LY294002 toward Human Glioma Cells In Vitro.International journal of molecular sciences · 2024Article
- Application of Thymol Vapors to Control Postharvest Decay Caused byFoods (Basel, Switzerland) · 2023Article
- Drug Delivery Application of Functional Nanomaterials Synthesized Using Natural Sources.Journal of functional biomaterials · 2023Review
- Article
- Citrus Waste as Source of Bioactive Compounds: Extraction and Utilization in Health and Food Industry.Molecules (Basel, Switzerland) · 2023Review
- An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy.Biomedicines · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Furanocoumarins are a specific group of secondary metabolites that commonly present in higher plants, such as citrus plants. The major furanocoumarins found in grapefruits (Citrus paradisi) include bergamottin, epoxybergamottin, and 6',7'-dihydroxybergamottin. During biosynthesis of these furanocoumarins, coumarins undergo biochemical modifications corresponding to a prenylation reaction catalyzed by the cytochrome P450 enzymes with the subsequent formation of furan rings. Because of undesirable interactions with several medications, many studies have developed methods for grapefruit furanocoumarin quantification that include high-performance liquid chromatography coupled with UV detector or mass spectrometry. The distribution of furanocoumarins in grapefruits is affected by several environmental conditions, such as processing techniques, storage temperature, and packing materials. In the past few years, grapefruit furanocoumarins have been demonstrated to exhibit several biological activities including antioxidative, -inflammatory, and -cancer activities as well as bone health promotion both in vitro and in vivo. Notably, furanocoumarins potently exerted antiproliferative activities against cancer cell growth through modulation of several molecular pathways, such as regulation of the signal transducer and activator of transcription 3, nuclear factor-κB, phosphatidylinositol-3-kinase/AKT, and mitogen-activated protein kinase expression. Therefore, based on this review, we suggest furanocoumarins may serve as bioactive components that contribute, at least in part, to the health benefits of grapefruit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.