ArticleJournal of food and drug analysis2016
Quantitative analysis of insulin in total parenteral nutrition bag in Taiwan.
Article in Journal of food and drug analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Topical Insulin Eye Drops: Stability and Safety of Two Compounded Formulations for Treating Persistent Corneal Epithelial Defects.Pharmaceutics · 2024Article
- Management of Hyperglycemia in Hospitalized Patients Receiving Parenteral Nutrition.Frontiers in clinical diabetes and healthcare · 2022Review
- Clinical Recommendations for Managing the Impact of Insulin Adsorptive Loss in Hospital and Diabetes Care.Journal of diabetes science and technology · 2021Article
- Addition of Regular Insulin to Ternary Parenteral Nutrition: A Stability Study.Pharmaceutics · 2021Article
- Capacity of Infusion Lines for Insulin Adsorption: Effect of Flow Rate on Total Adsorption.Journal of diabetes science and technology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regular insulin can reduce hyperglycemia when directly added to total parenteral nutrition (TPN) solutions. Insulin is not routinely added to all TPN solutions. For patients who require insulin prior to the initiation of TPN supplement, one-third to one-half of the usual total daily dose can be added to the TPN bag as regular human insulin. However, an incorrect dose or an interaction between insulin and the TPN bag material may affect blood sugar control in clinical practice. Therefore, it is important to quantitatively determine the final dose of insulin in the TPN bag. High performance liquid chromatography is a very powerful technique for determining the purity of proteins. The goal of this study was to use high-performance liquid chromatography to perform quantitative analysis of insulin in a TPN bag. The analysis was performed under different light conditions (UV, fluorescent, and darkness) and different temperatures (25°C and 2-8°C). The results show that adsorption of insulin on an ethylene vinyl acetate TPN bag is significantly higher than that on glass. Based on the results, it is evident that regular insulin should be administered separately from TPN to reduce cost and eliminate wasteful disposal of TPN solutions.
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Registered trials
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