Evidence map›Paper›PMID 28911357›Full record

Trial reportThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017

Pulmonary tuberculosis diagnostic practices among people living with the human immunodeficiency virus in Lesotho.

D E O'Connor, K Frederix, S Saito, L B Maama, Y Hirsch-Moverman, B Pitt, E Hayes-Larson, L Lebelo, M Shale, A A Howard

Abstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D E O'ConnorICAP at Columbia University, Mailman School of Public Health, New York, New York, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
K FrederixICAP at Columbia University, Maseru, Lesotho.
S SaitoICAP at Columbia University, Mailman School of Public Health, New York, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
L B MaamaNational Tuberculosis Program, Lesotho Ministry of Health, Maseru, Lesotho.
Y Hirsch-MovermanICAP at Columbia University, Mailman School of Public Health, New York, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
B PittICAP at Columbia University, Maseru, Lesotho.
E Hayes-LarsonICAP at Columbia University, Mailman School of Public Health, New York, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
L LebeloICAP at Columbia University, Maseru, Lesotho.
M ShaleICAP at Columbia University, Maseru, Lesotho.
A A HowardICAP at Columbia University, Mailman School of Public Health, New York, New York, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Funding

Global HIV Implementation Science Research Training Grant RenewalT32AI114398 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Yael R Hirsch-Moverman · 2014 to 2026
$4.1M
Preventing Childhood Tuberculosis in Lesotho (PREVENT Study)K01AI104351 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HIRSCH-MOVERMAN, YAEL R · 2014 to 2018
$635k
NIAID NIH HHS K01 AI104351NIAID NIH HHS T32 AI114398PEPFAR
6 · The paper itself

Abstract

settingTwelve health facilities in Berea District, Lesotho, that participated in the Start TB Patients on ART and Retain on Treatment (START) Study, a mixed-methods cluster-randomized trial evaluating a combination intervention package to improve early initiation of antiretroviral therapy (ART) and anti-tuberculosis treatment success among patients with tuberculosis (TB) and human immunodeficiency virus (HIV).

objectiveTo assess TB and HIV diagnostic practices among TB-HIV patients.

designA standardized survey assessed services at each facility at baseline. Routine clinical data were abstracted for all newly registered adult TB-HIV patients during the study period. Descriptive statistics were used to assess TB diagnostic practices, timing of the HIV diagnosis, and ART status at TB treatment initiation.

resultsBetween April 2013 and March 2015, 1233 TB-HIV patients were enrolled. Among 1215 patients with available data, 87.2% had pulmonary TB, of which 34.8% were bacteriologically confirmed, 40.9% tested negative and 24.3% were not tested. Among 1138 patients with available data, 53.3% had an existing HIV diagnosis, of whom 39.3% were ART-naïve.

conclusionsThe majority of pulmonary TB patients were clinically diagnosed, and many were unaware of their HIV status or were ART-naïve despite known status. The Test and Treat Strategy holds promise to prevent TB and reduce TB-related mortality among people living with HIV; however, enhanced TB diagnostic capacity and improved HIV case detection are urgently needed.

Indexed as

AdultAnti-HIV AgentsAntitubercular AgentsFemaleHIV InfectionsHumansLesothoMaleMiddle AgedTime FactorsTuberculosis, PulmonaryAnti-HIV AgentsAntitubercular Agents

Identifiers

PMID28911357
PMCPMC5652316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.