Evidence map›Paper›PMID 28911061›Full record

ReviewAnnals of oncology : official journal of the European Society for Medical Oncology2017

International cancer seminars: a focus on esophageal squamous cell carcinoma.

G Murphy, V McCormack, B Abedi-Ardekani, M Arnold, M C Camargo, N A Dar, S M Dawsey, A Etemadi, R C Fitzgerald, D E Fleischer and 29 more

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Annals of oncology : official journal of the European Society for Medical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04494009 (Randomized Phase II Trial of a PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma), which is not on this map. Cited by 112 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 4 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04494009 phase2active not recruitingnot on this mapstarted 2020, after this paper: background citation

Randomized Phase II Trial of a PD-1 Inhibitor INCMGA00012 as Consolidation Therapy After Definitive Concurrent Chemoradiotherapy for Patients With Locally Advanced Esophageal Squamous Cell Carcinoma (RHAPSODY)

TypeinterventionalSponsorAsan Medical CenterRan2020 to 2026Enrolled110ConditionsEsophageal CancerArmsINCMGA00012
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 4 syntheses or guidelines pooled it, 235 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 18 institutions in 12 countries.

G MurphyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
V McCormackSection of Environment and Radiation.
B Abedi-ArdekaniSection of Genetics.
M ArnoldCancer Surveillance, International Agency for Research on Cancer, Lyon, France.
M C CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
N A DarDepartment of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India.
S M DawseyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
A EtemadiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
R C FitzgeraldMRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, UK.
D E FleischerDepartment of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
N D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
A M GoldsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
S GopalUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
M HashemianDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
N HuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
P L HylandDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
B KaimilaUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
F KamangarDepartment of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, Maryland, USA.
R MalekzadehDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
C G MathewDepartment of Medical and Molecular Genetics, Kings College London.
D MenyaSchool of Public Health, Moi University, Eldoret, Kenya.
G MulimaUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
M M MwachiroTenwek Hospital, Bomet, Kenya.
A MwasamwajaKilimanjaro Christian Medical Centre, Moshi, Tanzania.
N PritchettDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
Y-L QiaoDepartment of Etiology and Carcinogenesis & Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
L F Ribeiro-PintoMolecular Carcinogenesis Program, Institute Nacional de Cancer, Sao Paulo, Brazil.
M RicciardoneNational Cancer Institute, Center for Global Health, National Institutes of Health, Bethesda, Maryland, USA.
J SchüzSection of Environment and Radiation.
F SitasSchool of Public Health, University of Sydney, New South Wales, Australia.
P R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
K Van LoonHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
S-M WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
W-Q WeiDepartment of Etiology and Carcinogenesis & Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
C P WildInternational Agency for Research on Cancer, Lyon, France.
C WuDepartment of Etiology and Carcinogenesis & Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
C C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
S J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
P BrennanSection of Genetics.
National Institutes of Health · USNational Cancer Institute · USChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity of Malawi · MWCentre International de Recherche sur le Cancer · FRPediatrics and Genetics · USInstituto Nacional do Câncer · BRKilimanjaro Christian Medical Centre · TZMayo Clinic in Arizona · USMoi University · KEMorgan State University · USMRC Cancer Unit · GBTehran University of Medical Sciences · IRTenwek Hospital · KEUniversity of California, San Francisco · USUniversity of Kashmir · INUniversity of the Witwatersrand · ZAUNSW Sydney · AU

Funding

Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Developing a clinical cohort of histopathologically characterized lymphomaK01TW009488 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GOPAL, SATISH · 2012 to 2016
$701k
Esophageal cancer in West KenyaR21CA191965 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI MCCORMACK, VALERIE · 2015 to 2016
$256k
Cancer Research UK 18119FIC NIH HHS D43 TW009343FIC NIH HHS K01 TW009488NCI NIH HHS R21 CA191965World Health Organization 001
6 · The paper itself

Abstract

The International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks RE et al. International cancer seminars: a focus on kidney cancer. Ann Oncol 2016; 27(8): 1382-1385]. In this, the second seminar, IARC and NCI convened a workshop in order to examine the state of the current science on esophageal squamous cell carcinoma etiology, genetics, early detection, treatment, and palliation, was reviewed to identify the most critical open research questions. The results of these discussions were summarized by formulating a series of 'difficult questions', which should inform and prioritize future research efforts.

Indexed as

Carcinoma, Squamous CellEsophageal NeoplasmsInternationalityEarly Detection of CancerEsophageal Squamous Cell CarcinomaHumansRisk Factorsclinical researchearly detectionepidemiologyesophageal squamous cell carcinoma (ESCC)genomics

Identifiers

PMID28911061
PMCPMC5834011
OpenAlexW2742416673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.