ReviewSchizophrenia bulletin2017
Motor Abnormalities: From Neurodevelopmental to Neurodegenerative Through "Functional" (Neuro)Psychiatric Disorders.
Review in Schizophrenia bulletin, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Expanding the phenotype of NEDAMSS with a psychiatric perspective: analysis of a new case, and a systematic review of the literature.European child & adolescent psychiatry · 2025Pooled it
- Diagnostic accuracy of keystroke dynamics as digital biomarkers for fine motor decline in neuropsychiatric disorders: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Paratonia in Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Motor Abnormalities and the Hierarchical Taxonomy of Psychopathology: Incorporating a Psychomotor Perspective Into a Hierarchical Dimensional Symptom Framework.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.European archives of psychiatry and clinical neuroscience · 2026Article
- A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders.Nature neuroscience · 2025Article
- Obsessive-compulsive and catatonic symptoms in the early stages of psychosis: Are they related?European archives of psychiatry and clinical neuroscience · 2025Article
- Article
- Examining Transdiagnostic Patterns of Motor Differences: Preliminary Findings From the Consortium for Motor Behavior in Neurodivergence (COMBINE).Journal of autism and developmental disorders · 2025Article
- A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations.Schizophrenia (Heidelberg, Germany) · 2025Article
- Atypical Cadherin FAT2 Is Required for Synaptic Integrity and Motor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurological soft signs in neurodegenerative dementias: Results of the DemeNSS study.PCN reports : psychiatry and clinical neurosciences · 2025Article
- The Association Between Childhood Impaired Motor Development and Adolescent Psychotic Experiences.Developmental psychobiology · 2025Article
- Multidimensional outcome of first-episode psychosis: a network analysis.Psychological medicine · 2025Article
- The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach.BMC psychiatry · 2025Article
- Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study.Brain communications · 2025Article
- Validity and reliability of the Box and Block Test for individuals with schizophrenia spectrum disorder.Frontiers in psychiatry · 2025Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Motor abnormalities (MAs) of severe mental disorders have been traditionally neglected both in clinical practice and research, although they are an increasing focus of attention because of their clinical and neurobiological relevance. For historical reasons, most of the literature on MAs has been focused to a great extent on schizophrenia, and as a consequence their prevalence and featural properties in other psychiatric or neuropsychiatric disorders are poorly known. In this article, we evaluated the extent to which catatonic, extrapyramidal and neurological soft signs, and their associated clinical features, are present transdiagnostically. Methods: We examined motor-related features in neurodevelopmental (schizophrenia, obsessive compulsive disorder, autism spectrum disorders), "functional" (nonschizophrenic nonaffective psychoses, mood disorders) and neurodegenerative (Alzheimer's disease) disorders. Examination of the literature revealed that there have been very few comparisons of motor-related features across diagnoses and we had to rely mainly in disorder-specific studies to compare it transdiagnostically. Results: One or more motor domains had a substantial prevalence in all the diagnoses examined. In "functional" disorders, MAs, and particularly catatonic signs, appear to be markers of episode severity; in chronic disorders, although with different degree of strength or evidence, all motor domains are indicators of both disorder severity and poor outcome; lastly, in Alzheimer's disease they are also indicators of disorder progression. Conclusions: MAs appear to represent a true transdiagnostic domain putatively sharing neurobiological mechanisms of neurodevelopmental, functional or neurodegenerative origin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.