ArticleThe international journal of neuropsychopharmacology2017
Ghrelin Serum Concentrations Are Associated with Treatment Response During Lithium Augmentation of Antidepressants.
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Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Transcutaneous vagal nerve stimulation modulates stress-induced plasma ghrelin levels: A double-blind, randomized, sham-controlled trial.Journal of affective disorders · 2023Trial
- Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin.International journal of molecular sciences · 2025Review
- The sex-specific relationship of ghrelin and cognition in Chinese han first-episode drug-naive major depressive disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?Current neuropharmacology · 2025Review
- A link between ghrelin and major depressive disorder: a mini review.Frontiers in psychiatry · 2024Review
- The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders.Depression and anxiety · 2024Review
- Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study.Translational psychiatry · 2023Article
- Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample.Frontiers in psychiatry · 2022Article
- The Good, the Bad and the Unknown Aspects of Ghrelin in Stress Coping and Stress-Related Psychiatric Disorders.Frontiers in synaptic neuroscience · 2020Review
- Anti-inflammatory Effect of Ghrelin in Lymphoblastoid Cell Lines From Children With Autism Spectrum Disorder.Frontiers in psychiatry · 2019Article
- Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder.Frontiers in psychiatry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Roland RickenDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Sandra BoppDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Peter SchlattmannDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Hubertus HimmerichDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Tom BschorDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Christoph RichterDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Samuel ElstnerDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Thomas J StammDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Brigitte Schulz-RateiDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Alexandra LingeslebenDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Friedel M ReischiesDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Philipp SterzerDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Stefan BorgwardtDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Michael BauerDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Rainer HellwegDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Undine E LangDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; Department of Statistics, Informatics and Documentation, Friedrich-Schiller-Universität Jena, Jena, Germany; Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany; King's College London, London, Great Britain; Department of Psychiatry and Psychotherapy, Schlosspark-Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Wenckebach Klinikum, Berlin, Germany; Vivantes Klinikum Kaulsdorf, Berlin, Germany; Department of Psychiatry and Psychotherapy, Evangelisches Krankenhaus Königin Elisabeth Herzberge gGmbH, Berlin, Germany; Department of Psychiatry and Psychotherapy, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany; Department of Psychiatry and Psychotherapy, Fliedner Klinik Berlin, Berlin, Germany; Department of Psychiatry and Psychotherapy, Vivantes Auguste-Viktoria-Klinikum, Berlin, Germany; Department of Psychiatry and Psychotherapy, Friedrich von Bodelschwingh-Klinik, Berlin, Germany; Department of Psychiatry and Psychotherapy, University Psychiatric Clinics (UPK), Switzerland; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Charité - Universitätsmedizin Berlin · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation. Method: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation. Results: In a linear mixed model analysis, we found a significant effect of response*time interaction (F1.81=9.48; P=.0028): under treatment, ghrelin levels increased in nonresponders and slightly decreased in responders to lithium augmentation. The covariate female gender had a significant positive effect (F1.83=4.69; P=.033), whereas time, response, appetite, and body mass index (kg/m2) did not show any significant effect on ghrelin levels (P>.05). Conclusion: This is the first study showing that the course of ghrelin levels separates responders and nonresponders to lithium augmentation. Present results support the hypothesis that ghrelin serum concentrations might be involved in response to pharmacological treatment of depression.
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AdultAgedAntidepressive AgentsBody Mass IndexCohort StudiesFemaleGhrelinHumansLithiumMajor Depressive DisorderMaleMiddle AgedTime FactorsAntidepressive AgentsGhrelinLithiumdepressionghrelinlithium augmentationresponsetherapy resistant depression
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