ArticleCarcinogenesis2017
Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model.
Article in Carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 68 citations in OpenAlex.
- From infection to cholangiocarcinoma: Why opisthorchiids break these rules.One health (Amsterdam, Netherlands) · 2026Review
- Paucisymptomatic opisthorchiasis in a non-endemic country: a neglected differential diagnosis?Infection · 2026Article
- Non-Invasive Diagnosis and Management of PancreaticAnimals : an open access journal from MDPI · 2026Article
- Structural and Spectroscopic Study of Benzoperimidines Derived from 1-Aminoanthraquinone and Their Application to Bioimaging.Molecules (Basel, Switzerland) · 2025Article
- Liver Fluke-Derived Molecules Accelerate Skin Repair Processes in a Mouse Model of Type 2 Diabetes Mellitus.International journal of molecular sciences · 2024Article
- Inflammatory responses toOpen veterinary journal · 2024Article
- Trematode Genomics and Proteomics.Advances in experimental medicine and biology · 2024Article
- The distribution and antibiotic-resistant characteristics and risk factors of pathogens associated with clinical biliary tract infection in humans.Frontiers in microbiology · 2024Article
- From the discovery of helminths to the discovery of their carcinogenic potential.Parasitology research · 2023Review
- Cancerogenic parasites in veterinary medicine: a narrative literature review.Infectious agents and cancer · 2023Review
- Omega-Class Glutathione Transferases Protect DNA from Oxidative Stress in Pathogenic Helminth Reproductive Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains.Foods (Basel, Switzerland) · 2022Review
- Xenobiotic-Metabolizing Enzymes in Trematodes.Biomedicines · 2022Review
- Jagged-1/Notch Pathway and Key Transient Markers Involved in Biliary Fibrosis duringTropical medicine and infectious disease · 2022Article
- Similarities and differences among the Opisthorchiidae liver flukes: insights fromParasitology · 2022Review
- Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini.PLoS pathogens · 2022Article
- Infectious Causes of Neoplasia in the Domestic Cat.Veterinary sciences · 2022Review
- Global changes in gene expression related toFood and waterborne parasitology · 2022Article
- Rapid assessment of Opisthorchis viverrini IgG antibody in serum: A potential diagnostic biomarker to predict risk of cholangiocarcinoma in regions endemic for opisthorchiasis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- DoesCells · 2021Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as group 1 agents and a major risk factor for cholangiocarcinoma. However, the carcinogenic potential of the infection with O. felineus is less clear. Here, we present findings that support the inclusion of O. felineus in the Group 1 list of biological carcinogens. Two discrete lines of evidence support the notion that infection with this liver fluke is carcinogenic. First, novel oxysterol-like metabolites detected by liquid chromatography-mass spectroscopy in the egg and adult developmental stages of O. felineus, and in bile, sera, and urine of liver fluke-infected hamsters exhibited marked similarity to oxysterol-like molecules known from O. viverrini. Numerous oxysterols and related DNA-adducts detected in the liver fluke eggs and in bile from infected hamsters suggested that infection-associated oxysterols induced chromosomal lesions in host cells. Second, histological analysis of liver sections from hamsters infected with O. felineus confirmed portal area enlargement, inflammation with severe periductal fibrosis and changes in the epithelium of the biliary tract characterized as biliary intraepithelial neoplasia, BilIN. The consonance of these biochemical and histopathological changes revealed that O. felineus infection in this rodent model induced precancerous lesions conducive to malignancy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.