Evidence map›Paper›PMID 28910857›Full record

ArticleCurrent protocols in chemical biology2017

A Guide to Quantitative Biomarker Assay Development using Whispering Gallery Mode Biosensors.

Heather M Robison, Ryan C Bailey

Open access · greenAbstract read
In one paragraph

Article in Current protocols in chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Chorioamnionitis-exposure alters serum cytokine trends in premature neonates.Journal of perinatology : official journal of the California Perinatal Association · 2023
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. On-Chip Optical Detection of Viruses: A Review.Advanced photonics research · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Heather M RobisonDepartment of Chemistry, University of Illinois at Urbana-Champaign.
Ryan C BaileyDepartment of Chemistry, University of Michigan, Ann Arbor.
University of Illinois Urbana-Champaign · USUniversity of Michigan–Ann Arbor · US

Funding

Multiplexed Platform to Probe Interactions at the Model Cell Membrane InterfaceR01GM110432 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAILEY, RYAN C · 2014 to 2017
$1.1M
Meso-plex miRNA and protein profiling for cancer diagnostics using chip-integrateR33CA177462 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAILEY, RYAN C, JOHNSON, MARK D · 2013 to 2015
$984k
NCI NIH HHS R33 CA177462NIGMS NIH HHS R01 GM110432
6 · The paper itself

Abstract

Whispering gallery mode (WGM) sensors are a class of powerful analytical techniques defined by the measurement of changes in the local refractive index at or near the sensor surface. When functionalized with target-specific capture agents, analyte binding can be measured with very low limits of detection. There are many geometric manifestations of WGM sensors, with chip-integrated silicon photonic devices first commercialized because of the robust, wafer-scale device fabrication, facile optical interrogation, and amenability to the creation of multiplexed sensor arrays. Using these arrays, a number of biomolecular targets have been detected in both label-free and label-enhanced assay formats. For example, sub-picomolar detection limits for multiple cytokines were achieved using an enzymatically enhanced sandwich immunoassay that showed high analyte specificity suitable for detection in complex, clinical matrices. This protocol describes a generalizable approach for the development of quantitative, multiplexed immunoassays using silicon photonic microrings as an example WGM platform. © 2017 by John Wiley & Sons, Inc.

Indexed as

BiomarkersBiosensing TechniquesImmunoassaySiliconBiomarkersSiliconbiomarkerimmunoassaymultiplexprotein detectionquantitative analysiswhispering gallery mode sensors

Identifiers

PMID28910857
PMCPMC5657521
OpenAlexW2766479496

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.