Evidence map›Paper›PMID 28910824›Full record

ArticleBritish journal of cancer2017

Occupational solvent exposure and risk of glioma in the INTEROCC study.

Geza Benke, Michelle C Turner, Sarah Fleming, Jordi Figuerola, Laurel Kincl, Lesley Richardson, Maria Blettner, Martine Hours, Daniel Krewski, David McLean and 7 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 9 countries.

Geza BenkeDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne 3004, Australia.
Michelle C TurnerBarcelona Institute for Global Health (ISGlobal), Barcelona 08036, Spain.
Sarah FlemingLeeds Institute of Cardiovascular and Metabolic Medicine, Institute of Cancer &Pathology, University of Leeds, Leeds LS2 9LN, UK.
Jordi FiguerolaBarcelona Institute for Global Health (ISGlobal), Barcelona 08036, Spain.
Laurel KinclEnvironmental and Occupational Health program in the College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.
Lesley RichardsonUniversity of Montreal Hospital Research Centre (CRCHUM), Montreal H2X OA9, Canada.
Maria BlettnerInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes-Gutenberg University Mainz, Mainz 55131, Germany.
Martine HoursUnité Mixte de Recherche Epidémiologique Transport Travail Environnement Université Lyon 1/IFSTTAR, Université de Lyon, Lyon 69675, France.
Daniel KrewskiMcLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa K1H 8M5, Canada.
David McLeanCentre for Public Health Research, Massey University, Wellington 6140, New Zealand.
Marie-Elise ParentINRS-Institut Armand-Frappier, Université du Québec, Laval H7V 1B7, Canada.
Siegal SadetzkiThe Cancer &Radiation Epidemiology Unit, The Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer 52620, Israel.
Klaus SchlaeferGerman Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Brigitte SchlehoferGerman Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Jack SiemiatyckiUniversity of Montreal Hospital Research Centre (CRCHUM), Montreal H2X OA9, Canada.
Martie van TongerenInstitute of Occupational Medicine, Edinburgh EH14 4AP, UK.
Elisabeth CardisBarcelona Institute for Global Health (ISGlobal), Barcelona 08036, Spain.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESUniversité de Montréal · CAGerman Cancer Research Center · DEHeidelberg University · DEInstitute of Occupational Medicine · GBInstitut National de la Recherche Scientifique · CAMassey University · NZMonash University · AUOregon State University · USPompeu Fabra University · ESSheba Medical Center · ILUniversité Claude Bernard Lyon 1 · FRUniversity Medical Center of the Johannes Gutenberg University Mainz · DEUniversity of Leeds · GBUniversity of Ottawa · CA

Funding

Occupational exposures and brain cancerR01CA124759 · NCI · INTERNATIONAL AGENCY FOR RES ON CANCER · PI CARDIS, ELISABETH · 2007 to 2010
$1.5M
NCI NIH HHS R01 CA124759
6 · The paper itself

Abstract

backgroundThe aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study. We also investigated associations according to tumour grade.

methodsData from the seven countries were standardised and then combined into one aggregate data set. Pooled odds ratios (ORs) were estimated for adjusted models that included sex, age, country-region of residence and level of educational attainment. Exposures to any solvent or 11 specific solvents or subgroups were assessed using a modified version of the FINJEM job exposure matrix (JEM) specifically developed for the study, called INTEROCC-JEM.

resultsAnalysis included 2000 glioma cases and 5565 controls. For glioma and ever/never exposure to any solvent, the OR was 0.91 (95% confidence interval: 0.74-1.11). All ORs were <1.0 for specific solvents/subgroups. There were no increases in risk according to high or low grade of tumour.

conclusionsThe results of this study show no consistent associations for any solvent exposures overall or by grade of tumour.

Indexed as

SolventsAdolescentAdultAgedAge FactorsAustraliaBrain NeoplasmsCanadaCase-Control StudiesFemaleFranceGermanyGliomaHumansIsraelMaleSolvents

Identifiers

PMID28910824
PMCPMC5674105
OpenAlexW2756366108

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.