ArticleHuman heredity2016
Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
Article in Human heredity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.bioRxiv : the preprint server for biology · 2025Article
- Consanguineous Marriage: Law and Public Health.Health care analysis : HCA : journal of health philosophy and policy · 2025Article
- Familial Searching utilising the National Forensic DNA Database of South Africa (NFDD-ZA) to aid in the identification of Missing Persons and Unidentified Human Remains.Forensic science international. Synergy · 2025Article
- Phasing millions of samples achieves near perfect accuracy, enabling parent-of-origin analyses.HGG advances · 2025Article
- Ancient DNA reveals diverse community organizations in the 5th millennium BCE Carpathian Basin.Nature communications · 2025Article
- A genomic tale of inbreeding in western Mediterranean human populations.Human genetics · 2025Article
- The distribution of regions of homozygosity (ROH) among consanguineous populations-implications for a routine genetic counseling service.Journal of human genetics · 2025Article
- Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing.G3 (Bethesda, Md.) · 2024Article
- The coefficients of inbreeding revealed by ROH study among inbred individuals belonging to each type of the first cousin marriage: A preliminary report from North India.Genes & genomics · 2023Article
- Privacy-aware estimation of relatedness in admixed populations.Briefings in bioinformatics · 2022Article
- Reconstructing the history of founder events using genome-wide patterns of allele sharing across individuals.PLoS genetics · 2022Article
- The effect of consanguinity on coalescence times on the X chromosome.Theoretical population biology · 2021Article
- Long Runs of Homozygosity Are Correlated with Marriage Preferences across Global Population Samples.Human biology · 2021Article
- FTheoretical population biology · 2020Article
- Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer's Disease.Frontiers in genetics · 2020Article
- Characterization of Prevalence and Health Consequences of Uniparental Disomy in Four Million Individuals from the General Population.American journal of human genetics · 2019Article
- Ancestry-Dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity.American journal of human genetics · 2019Article
- Article
- Understanding the Hidden Complexity of Latin American Population Isolates.American journal of human genetics · 2018Article
- Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.American journal of human genetics · 2018Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesRecent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study runs of homozygosity (ROH) in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide.
methodsBy sorting ROH into 3 length classes (short, intermediate, and long), we evaluate the impact of demographic processes on genomic patterns in Jewish populations.
resultsWe find that the portion of the genome appearing in long ROH - the length class most directly related to recent consanguinity - closely accords with data gathered from interviews during the 1950s on frequencies of consanguineous unions in various Jewish groups.
conclusionThe high correlation between 1950s consanguinity levels and coverage by long ROH explains differences across populations in ROH patterns. The dissection of ROH into length classes and the comparison to consanguinity data assist in understanding a number of additional phenomena, including similarities of Jewish populations to Middle Eastern, European, and Central and South Asian non-Jewish populations in short ROH patterns, relative lengths of identity-by-descent tracts in different Jewish groups, and the "population isolate" status of the Ashkenazi Jews.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.