ArticleCell host & microbe2017
Host Genetic Control of the Oral Microbiome in Health and Disease.
Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Impact of Children's Dietary Habits on the Oral Microbiome: A Systematic Review.Nutrients · 2026Pooled it
- Meta-analysis defines predominant shared microbial responses in various diseases and a specific inflammatory bowel disease signal.Genome biology · 2022Pooled it
- Bibliometric analysis of research trends and hotspots on the microbial mediation effects.Antonie van Leeuwenhoek · 2026Article
- Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins.NPJ biofilms and microbiomes · 2026Article
- Article
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- A New Framework to Empower Ecosystem Assessment Through the Integration of eDNA Inventories, Graph Theory and Niche Modelling.Ecology letters · 2026Article
- Population-based characterisation of child and adolescent oral bacterial microbiomes.Microbiome · 2026Article
- Integrative Analysis ofDentistry journal · 2026Article
- The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.Journal of cardiovascular translational research · 2026Review
- Article
- Ecological and evolutionary dynamics of the oral microbiome across childhood.bioRxiv : the preprint server for biology · 2026Article
- Guangdong Biobank Cohort (GDBC) study.European journal of epidemiology · 2026Article
- Effects of cigarette smoking on the oral microbiome in adolescents.Scientific reports · 2026Article
- A Review of the Impact of Green Tea (Current pharmaceutical design · 2026Review
- Multicohort external validation ofFrontiers in cellular and infection microbiology · 2026Article
- Omics Sciences in Dentistry: A Narrative Review on Diagnostic and Therapeutic Applications for Prevalent Oral Diseases.Diagnostics (Basel, Switzerland) · 2025Review
- Causal Association Between Oral Microbiota and Major Salivary Gland Cancer: A Bidirectional Two-Sample Mendelian Randomization Study.Oral health & preventive dentistry · 2025Article
- Tooth Decay: Genetic and Epigenetic Insights Driving the Development of Anti-Caries Vaccines.Genes · 2025Review
- An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota.Clinics and practice · 2025Review
67 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged 5-11. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.