ArticleJournal of the American Chemical Society2017
Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Programmable Host-Guest Recognition for Shape-Shifting Supramolecular Nanostructure States.ACS nano · 2025Article
- Molecules that Generate Fingerprints: A New Class of Fluorescent Sensors for Chemical Biology, Medical Diagnosis, and Cryptography.Accounts of chemical research · 2023Review
- Mismatched covalent and noncovalent templating leads to large coiled coil-templated macrocycles.Chemical science · 2023Article
- Article
- Memory, switches, and an OR-port through bistability in chemically fueled crystals.Nature communications · 2022Article
- Thioesters provide a plausible prebiotic path to proto-peptides.Nature communications · 2022Article
- Construction of Supramolecular Systems That Achieve Lifelike Functions.Materials (Basel, Switzerland) · 2022Review
- An Optical Probe for Real-Time Monitoring of Self-Replicator Emergence and Distinguishing between Replicators.Journal of the American Chemical Society · 2022Article
- Hierarchical self-assembly of aromatic peptide conjugates into supramolecular polymers: it takes two to tango.Chemical science · 2022Review
- tRNA sequences can assemble into a replicator.eLife · 2021Article
- Article
- Chemical control of peptide material phase transitions.Chemical science · 2021Article
- Hydrogen-bonded host-guest systems are stable in ionic liquids.Scientific reports · 2020Article
- Narcissistic, Integrative, and Kinetic Self-Sorting within a System of Coordination Cages.Journal of the American Chemical Society · 2020Article
- Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine.Biomacromolecules · 2019Article
- Factors that determine thione(thiol)-disulfide interconversion in a bis(thiosemicarbazone) copper(ii) complex.RSC advances · 2019Article
- Models of Replicator Proliferation Involving Differential Replicator Subunit Stability.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge regarding the early steps in the formation of evolvable life and what constitutes the minimal molecular basis of life remains far from complete. The recent emergence of systems chemistry reinvigorated the investigation of systems of self-replicating molecules to address these questions. Most of these studies focus on single replicators and the effects of replicators on the emergence of other replicators remains under-investigated. Here we show the cross-catalyzed emergence of a novel self-replicator from a dynamic combinatorial library made from a threonine containing peptide building block, which, by itself, only forms trimers and tetramers that do not replicate. Upon seeding of this library with different replicators of different macrocycle size (hexamers and octamers), we observed the emergence of hexamer replicator consisting of six units of the threonine peptide only when it is seeded with an octamer replicator containing eight units of a serine building block. These results reveal for the first time how a new replicator can emerge in a process that relies critically on the assistance by another replicator through cross-catalysis and that replicator composition is history dependent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.