ArticlePloS one2017
Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Does the incorporation of strontium into calcium phosphate improve bone repair? A meta-analysis.BMC oral health · 2022Pooled it
- Synthesis and Cytocompatibility of Bacterial Nanocellulose-Hydroxyapatite Biocomposites with Mg, Cu, Zn, and Sr Substitution.ACS omega · 2026Article
- Osteogenic Potential of a Three-Phase Strontium- and Silicon-Doped Tricalcium Silicate Cement on Dental Pulp Stem Cells: An In Vitro Study.Clinical and experimental dental research · 2026Article
- Pullulan-dextran composite beads as bone fillers: from material design and industrial production to clinical application in oral surgery.Frontiers in bioengineering and biotechnology · 2026Article
- Strontium-Substituted Calcium Orthophosphates: Structure, Stability, Morphology, and Biomedical Applications.International journal of molecular sciences · 2025Review
- Bone Regeneration in Small and Large Segmental Bone Defect Models after Radiotherapy Using Injectable Polymer-Based Biodegradable Materials Containing Strontium-Doped Hydroxyapatite Particles.International journal of molecular sciences · 2023Article
- Nanocomposite Based on HA/PVTMS/ClSensors (Basel, Switzerland) · 2022Article
- Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes.International journal of molecular sciences · 2022Review
- Therapeutic approaches to activate the canonical Wnt pathway for bone regeneration.Journal of tissue engineering and regenerative medicine · 2022Review
- Recent advances in biofunctional guided bone regeneration materials for repairing defective alveolar and maxillofacial bone: A review.The Japanese dental science review · 2022Review
- Review
- Biomimetic PLGA/Strontium-Zinc Nano Hydroxyapatite Composite Scaffolds for Bone Regeneration.Journal of functional biomaterials · 2022Article
- Fabrication, characterization, and optimization of a novel copper-incorporated chitosan/gelatin-based scaffold for bone tissue engineering applications.BioImpacts : BI · 2022Article
- Recent developments in strontium-based biocomposites for bone regeneration.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020Review
- Comprehensive In Vitro Testing of Calcium Phosphate-Based Bioceramics with Orthopedic and Dentistry Applications.Materials (Basel, Switzerland) · 2019Review
- Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods.Materials (Basel, Switzerland) · 2018Review
- Immunohistochemical evaluation after Sr-enriched biphasic ceramic implantation in rabbits femoral neck: comparison of seven different bone conditions.Journal of materials science. Materials in medicine · 2018Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies performed using polysaccharide-based matrices supplemented with hydroxyapatite (HA) particles showed their ability to form in subcutaneous and intramuscular sites a mineralized and osteoid tissue. Our objectives are to optimize the HA content in the matrix and to test the combination of HA with strontium (Sr-HA) to increase the matrix bioactivity. First, non-doped Sr-HA powders were combined to the matrix at three different ratios and were implanted subcutaneously for 2 and 4 weeks. Interestingly, matrices showed radiolucent properties before implantation. Quantitative analysis of micro-CT data evidenced a significant increase of mineralized tissue formed ectopically with time of implantation and allowed us to select the best ratio of HA to polysaccharides of 30% (w/w). Then, two Sr-substitution of 8% and 50% were incorporated in the HA powders (8Sr-HA and 50Sr-HA). Both Sr-HA were chemically characterized and dispersed in matrices. In vitro studies performed with human mesenchymal stem cells (MSCs) demonstrated the absence of cytotoxicity of the Sr-doped matrices whatever the amount of incorporated Sr. They also supported osteoblastic differentiation and activated the expression of one late osteoblastic marker involved in the mineralization process i.e. osteopontin. In vivo, subcutaneous implantation of these Sr-doped matrices induced osteoid tissue and blood vessels formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.